研究業績

Outstanding discoveries

  • Matsuura K, Sawai H, Ikeo K, et al: Genome-wide association study identifies a TLL1 variant associated with developing hepatocellular carcinoma after eradication of hepatitis C virus. Gastroenterology (Feb 2017, Epub ahead of print)
    C型肝炎ウイルス(HCV) 排除後の肝発癌に関わる遺伝要因を世界で初めて発見しました。HCV排除後の肝発癌リスクの高い患者群を絞り込むことが可能となり、肝癌の早期発見・治療につながる成果です。
  • Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, et al: Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cirrhosis in the Japanese population. Hum Mol Genet (Jan 2017, Epub ahead of print).
    全国の80ヶ所の拠点病院と連携して、オールジャパン体制で原発性胆汁性胆管炎(PBC)の分子コホート研究を推進することにより、日本人の新たなPBC疾患感受性遺伝子を同定しました。2012年にAm.J.Hum.Genet.に報告した日本人PBC疾患感受性遺伝子に続く成果で、今後はPBCの疾患発症経路の解明がすすむものと期待されます。
  • Miyadera H, Ohashi J, Lernmark Å, et al: Cell surface MHC density profiling reveals instability of autoimmunity-associated HLA. J Clin Invest 125(1): 275-91, 2015.
    1型糖尿病などの自己免疫疾患の発症に関連することが知られているHLA-DQタンパク質の安定性が、HLA-DQ遺伝子の型によって大きく異なることを見出しました。自己免疫疾患の発症機序の解明に貢献する成果です。
  • Okada Y, Wu D, Trynka G, et al: Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506(7488): 376-381, 2014.
  • Okada Y, Terao C, Ikari K, et al: Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 44(5): 511-517, 2012.
  • Okamoto K, Tokunaga K, Doi K, et al: Common variation in GPC5 is associated with acquired nephrotic syndrome. Nat Genet 43(5):459-463, 2011.
    GWASを用いて、腎臓にある糸球体の異常によって蛋白尿などの症状がでるネフローゼ症候群の感受性遺伝子GPC5を同定しました。さらに、GPC5が腎臓において血液の不要な成分のみを尿として排出するフィルター構造の維持に関与していることも発見しました。
  • Kornum BR, Kawashima M, Faraco J, et al: Common variants in P2RY11 are associated with narcolepsy. Nat Genet 43(1):66-71, 2011.
  • Saito T, Fukai A, Mabuchi A, et al: Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med 16(6):678-686, 2010.
  • HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, et al: Indian Genome Variation Consortium. Mapping human genetic diversity in Asia. Science 326(5959):1541-1545, 2009.
  • Tanaka Y, Nishida N, Sugiyama M, et al: Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 41(10):1105-1109, 2009.
    GWASを用いて、C型慢性肝炎の治療応答性とIL28Bとの非常に強い関連を見出しました。現在では、IL28B遺伝子型を治療前に検査することで、治療効果を高い確率で予測することができるようになっています。
  • Hallmayer J, Faraco J, Lin L, et al: Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 41(6):708-711, 2009.
  • Miyagawa T, Kawashima M, Nishida N, et al: Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nat Genet 40(11):1324-1328, 2008.
    代表的な過眠症であるナルコレプシーの新たな感受性遺伝子同定のためにゲノムワイド関連解析を行い、CPT1B遺伝子の近傍に位置するSNPがナルコレプシーと関連することを見出しました。
  • Yasuda K, Miyake K, Horikawa Y, et al: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40(9):1092-1097, 2008.
  • Nakatsuji N, Nakjima F, and Tokunaga K: HLA-haplotype banking and iPS cells. Nat Biotech 26(7): 739-740, 2008.
  • Yoshiura K, Kinoshita A, Ishida T, et al: A SNP in the ABCC11 gene is the determinant of human earwax type. Nat Genet 38(3):324-330, 2006.
  • Kobayashi K, Nakahori Y, Miyake M, et al: An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature 394(6691):388-392, 1998.

in press

  • Sugiura-Ogasawara M*, Omae Y*(equal contribution), Kawashima M, Toyo-oka L, Khor S-S, Sawai H, Horita T, Atsumi T, Murashima A, Fujita D, Fujita T, Morimoto S, Morishita E, Katsuragi S, Kitaori T, Katano K, Ozaki Y, and Tokunaga K. The first genome-wide association study identifying new susceptibility loci for obstetric antiphospholipid syndrome. J Hum Genet (in press)

2017

  • Trinks J, Nishida N, Hulaniuk ML, Caputo M, Tsuchiura T, Marciano S, Haddad L, Blejer J, Bartoli S, Ameigeiras B, Frías SE, Vistarini C, Heinrich F, Remondegui C, Ceballos S, Echenique G, Charre Samman M, D'Amico C, Rojas A, Martínez A, Ridruejo E, Fernández RJ, Pratx LB, Salamone H, Nuñez F, Galdame O, Gadano A, Corach D, Sugiyama M, Flichman D, Tokunaga K, and Mizokami M. Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population. Liver Int (March 2017, Epub ahead of print)
  • Wakamatsu TH, Ueta M, Tokunaga K, Okada Y, Loureiro RR, Costa KA, Sallum JM, Milhomens JA, Inoue C, Sotozono C, Gomes JÁ, and Kinoshita S. Human leukocyte antigen class I genes associated with Stevens-Johnson syndrome and severe ocular complications following use of cold medicine in a Brazilian population. JAMA Ophthalmol (March 2017, Epub ahead of print)
  • Matsuura K, Sawai H, Ikeo K, Ogawa S, Iio E, Isogawa M, Shimada N, Komori A, Toyoda H, Kumada T, Namisaki T, Yoshiji H, Sakamoto N, Nakagawa M, Asahina Y, Kurosaki M, Izumi N, Enomoto N, Kusakabe A, Kajiwara E, Itoh Y, Ide T, Tamori A, Matsubara M, Kawada N, Shirabe K, Tomita E, Honda M, Kaneko S, Nishina S, Suetsugu A, Hiasa Y, Watanabe H, Genda T, Sakaida I, Nishiguchi S, Takaguchi K, Tanaka E, Sugihara J, Shimada M, Kondo Y, Kawai Y, Kojima K, Nagasaki M, Tokunaga K, and Tanaka Y. Genome-wide association study identifies a TLL1 variant associated with developing hepatocellular carcinoma after eradication of hepatitis C virus. Gastroenterology (Feb 2017, Epub ahead of print)
  • Nagao Y, Nishida N, Toyo-oka L, Kawaguchi A, Amoroso A, Carrozzo M, Sata M, Mizokami M, Tokunaga K, and Tanaka Y. Genome-wide association study identifies risk variants for lichen planus in patients with hepatitis C virus infection. Clin Gastroenterol Hepatol (Jan 2017, Epub ahead of print)
  • Ikeda M, Takahashi A, Kamatani Y, Okahisa Y, Kunugi H, Mori N, Sasaki T, Ohmori T, Okamoto Y, Kawasaki H, Shimodera S, Kato T, Yoneda H, Yoshimura R, Iyo M, Matsuda K, Akiyama M, Ashikawa K, Kashiwase K, Tokunaga K, Kondo K, Saito T, Shimasaki A, Kawase K, Kitajima T, Matsuo K, Itokawa M, Someya T, Inada T, Hashimoto R, Inoue T, Akiyama K, Tanii H, Arai H, Kanba S, Ozaki N, Kusumi I, Yoshikawa T, Kubo M and Iwata N. A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder. Mol Psychiatry (Jan 2017, Epub ahead of print)
  • Ueta M*, Sawai H* (equal contribution), Shingaki R, Kawai Y, Sotozono C, Kojima K, Yoon K-C, Kim MK, Seo KY, Joo C-K, Nagasaki M, Kinoshita S, and Tokunaga K. Genome-wide association study using the ethnicity-specific Japonica array: Identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications. J Hum Genet 62(4): 485-489, 2017.
  • Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, Shibata H, Himoto T, Murata K, Miyake Y, Ebinuma H, Taniai M, Joshita S, Nikami T, Ota H, Kouno H, Kouno H, Nakamuta M, Fukushima N, Kohjima M, Komatsu T, Komeda T, Ohara Y, Muro T, Yamashita T, Yoshizawa K, Nakamura Y, Shimada M, Hirashima N, Sugi K, Ario K, Takesaki E, Naganuma A, Mano H, Yamashita H, Matsushita K, Yamauchi K, Makita F, Nishimura H, Furuta K, Takahashi N, Kikuchi M, Masaki N, Tanaka T, Tamura S, Mori A, Yagi S, Shirabe K, Komori A, Migita K, Ito M, Nagaoka S, Abiru S, Yatsuhashi H, Yasunami M, Shimoda S, Harada K, Egawa H, Maehara Y, Uemoto S, Kokudo N, Takikawa H, Ishibashi H, Chayama K, Mizokami M, Nagasaki M, Tokunaga K, and Nakamura M. Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cirrhosis in the Japanese population. Hum Mol Genet (Jan 2017, Epub ahead of print)
  • Shimada-Sugimoto M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, and Sasaki T. Epigenome-wide association study of DNA methylation in panic disorder. Clin Epigenet 9: e6, 2017.

2016

  • Thiri M, Honda K, Kashiwase K, Mabuchi A, Suzuki H, Watanabe K, Nakayama M, Watanabe T, Doi K, Tokunaga K, and Noiri E. High-density association mapping and interaction analysis of PLA2R1 and HLA regions with idiopathic membranous nephropathy in Japanese. Sci Rep e38189, 2016.
  • Wattanapokayakit S, Mushiroda T, Yanai H, Wichukchinda N, Chuchottawon C, Nedsuwan S, Rojanawiwat A, Denjanta S, Kantima T, Wongyai J, Suwankesawong W, Rungapiromnan W, Kidkeukarun R, Bamrungram W, Chaiwong A, Suvichapanich S, Mahasirimongkol S, and Tokunaga K. NAT2 slow acetylator associated with anti-tuberculosis drug-induced liver injury in Thai patients. Int J Tuberc Lung Dis 20: 1364-1369, 2016.
  • Matsunami K, Nishida N, Kaneko N, Ikeo K, Toyo-oka L, Takeuchi H, Matsuura K, Tamori A, Nomura H, Yoshiji H, Imamura M, Masaki N, Hayakawa T, Ide T, Shimada N, Ikeda F, Hino K, Nishiguchi S, Okuse C, Nojiri S, Sawamoto K, Tokunaga K, Joh T, and Tanaka Y. Genome-wide association study identifies ZNF354C variants associated with depression by interferon-based therapy for chronic hepatitis C. PLoS One 11: e0164418, 2016.
  • Smittipat N, Juthayothin T, Billamas P, Jaitrong S, Rukseree K, Dokladda K, Chaiyasirinroje B, Disratthakit A, Chaiprasert A, Mahasirimongkol S, Yanai H, Yamada N, Tokunaga K, and Palittapongarnpim P. Mutations in rrs, rpsL and gidB in streptomycin-resistant Mycobacterium tuberculosis isolates from Thailand. J Glob Antimicrob Resist 4: 5-10, 2016.
  • Otowa T, Kawamura Y, Tsutsumi A, Kawakami N, Kan C, Shimada T, Umekage T, Kasai K, Tokunaga K, and Sasaki T. The first pilot genome-wide gene–environment study of depression in the Japanese population. PLoS One 11: e0160823, 2016.
  • Sun YH, Irwanto A, Toyo-oka L, Hong MH, Liu H, Andiappan AK, Choi HC, Hitomi Y, Yu GQ, Yu YX, Bao FF, Wang C, Fu X, Yue ZH, Wang HL, Zhang HM, Kawashima M, Kojima K, Nagasaki M, Nakamura M, Yang SK, Ye BD, Denise Y, Rotzschke O, Song KY, Tokunaga K, Zhang FR, and Liu JJ. Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn's disease and leprosy. Sci Rep 6: e31429, 2016.
  • Hoshino A, Saitoh M, Miyagawa T, Kubota M, Takanashi J, Miyamoto A, Tokunaga K, Oka A, and Mizuguchi M. Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy. Genes Immun 17: 367-369, 2016.
  • Liu J, Ye Z, Mayer JG, Hoch BA, Green C, Rolak L, Cold C, Khor SS, Zheng X, Miyagawa T, Tokunaga K, Brilliant MH, and Hebbring SJ. Phenome-wide association study maps new diseases to the human major histocompatibility complex region. J Med Genet 53: 681-689, 2016.
  • Yamasaki M, Miyagawa T, Toyoda H, Khor S-S, Liu X, Kuwabara H, Kano Y, Shimada T, Sugiyama T, Nishida H, Sugaya N, Tochigi M, Otowa T, Okazaki Y, Kaiya H, Kawamura Y, Miyashita A, Kuwano R, Kasai K, Tanii H, Honda Y, Honda M, and Tokunaga K. Evaluation of polygenic risks for narcolepsy and essential Hypersomnia. J Hum Genet 61: 873-878, 2016.
  • Yuliwulandari R, Susilowati RW, Wicaksono BD, Viyati K, Prayuni K, Razari I, Kristin E, Syafrizal, Subagyo, Diana ES, Setiawati S, Ariyani A, Mahasirimongkol S, Yanai H, Mushiroda T, and Tokunaga K. NAT2 variants are associated with drug-induced liver injury caused by anti-tuberculosis drugs in Indonesian patients with tuberculosis. J Hum Genet61: 533-537, 2016.
  • Mushiroda T, Yanai H, Yoshiyama T, Sasaki Y, Okumura M, Ogata H, and Tokunaga K: Development of a prediction system for anti-tuberculosis drug-induced liver injury in Japanese patients. Hum Genome Var 3:16014, 2016.
  • Nishida N, Ohashi J, Khor S-S, Sugiyama M, Tsuchiura T, Sawai H, Hino K, Honda M, Kaneko S, Yatsuhashi H, Yokosuka O, Koike k, Kurosaki M, Izumi N, Korenaga M, Kang J-H, Tanaka E, Akinobu Taketomi A, Eguchi Y, Sakamoto N, Yamamoto K, Tamori A, Sakaida I, Hige S, Itoh Y, Mochida S, Mita E, Takikawa Y, Ide T, Hiasa Y, Hiroto Kojima H, Yamamoto K, Nakamura M, Saji H, Sasazuki T, Kanto T, Tokunaga K, and Mizokami M. Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis. Sci Rep 6: 24767, 2016.
  • Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor S-S, Omae Y, Toyo-oka L, Sugaya N, Kawamura Y, Umekage T, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Okazaki Y, Tokunaga K, and Sasaki T. Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population. Hum Genome Var 3: 16001, 2016.
  • Nakauchi A, Wong JH, Mahasirimongkol S, Yanai H, Yuliwulandari R, Akihiko Mabuchi A, Liu X, Mushiroda T, Wattanapokayakit S, Miyagawa T, Keicho N, and Tokunaga K. Identification of ITPA on Chromosome 20 as a susceptibility gene to young-onset Tuberculosis. Hum Genome Var 3: 15067, 2016.
  • Liu X, Shimada T, Otowa T, Wu Y-Y, Kawamura Y, Tochigi M, Iwata Y, Umekage T, Toyota T, Maekawa M, Iwayama Y, Suzuki K, Kakiuchi C, Kuwabara H, Kano Y, Nishida H, Sugiyama T, Kato N, Chen CH, Mori N, Yamada K, Yoshikawa T, Kasai K, Tokunaga K, Sasaki T, and Gau SS-F. Genome-wide association study of autism spectrum disorder in the East Asian populations. Autism Res 9(3): 340-349, 2016

2015年

  • Nishida N, Ohashi J, Sugiyama M, Tsuchiura T, Yamamoto K, Hino K, Honda M, Kaneko S, Yatsuhashi H, Koike K, Yokosuka O, Tanaka E, Taketomi A, Kurosaki M, Izumi N, Sakamoto N, Eguchi Y, Sasazuki T, Tokunaga K, and Mizokami M. Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese. Tissue Antigens 86(6):406-12, 2015
  • Howe AS, Buttenschøn HN, Bani-Fatemi A, Maron E, Otowa T, Erhardt A, Binder EB, Gregersen NO, Mors O, Woldbye DP, Domschke K, Reif A, Shlik J, Kõks S, Kawamura Y, Miyashita A, Kuwano R, Tokunaga K, Tanii H, Jordan W, Smoller JW, Sasaki T, Koszycki D, and Luca VD. Candidate genes in panic disorder: Meta-analyses of 23 common variants in major anxiogenic pathways. Mol Psychiatry 21(5): 665-79, 2015
  • Miyadera H, Bungener LB, Kusano S, Yokoyama S, Tokunaga K, and Hepkema BG. Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07. Tissue Antigens 86(6): 413-418, 2015.
  • Miyadera H and Tokunaga K. Association of HLA with autoimmune diseases- challenges in identifying the mechanism of allele-specific disease susceptibility. J Hum Genet 60(11): 697-702, 2015.
  • Liu X, Shimada T, Otowa T, Wu Y-Y, Kawamura Y, Tochigi M, Iwata Y, Umekage T, Toyota T, Maekawa M, Iwayama Y, Suzuki K, Kakiuchi C, Kuwabara H, Kano Y, Nishida H, Sugiyama T, Kato N, Chen CH, Mori N, Yamada K, Yoshikawa T, Kasai K, Tokunaga K, Sasaki T, and Gau SS-F. Genome-wide association study of autism spectrum disorder in the East Asian populations. Autism Res (August 2015, Epub ahead of print)
  • Khor SS, Yang W, Kawashima M, Kamitsuji S, Zheng X, Nishida N, Sawai H, Toyoda H, Miyagawa T, Honda M, Kamatani N, and Tokunaga K. High-accuracy imputation for HLA class I and II genes based on high-resolution SNP data of population-specific references. Pharmacogenomics J. (Feb 2015, Epub ahead of print)Khor SS, Yang WS, Kawashima M, Kamitsuji S, Zheng XW, Nishida N, Sawai H, Toyoda H, Miyagawa T, Honda M, Kamatani N, and Tokunaga K: High-accuracy imputation for HLA class I and II genes based on high-resolution SNP data of population-specific references. Pharmacogenomics J 15(6): 530-537, 2015.
  • Hu Y, Yoshida K, Cologne JB, Maki M, Morishita Y, Sasaki K, Hayashi I, Ohishi W, Hida A, kyoizumi S, Kusunoki Y, Tokunaga K, Nakachi K, and Hayashi T. CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors. Hum Genome Var 2: 15035, 2015.
  • Miyagawa T, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Y Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Ikegami A, Wada Y, Imai M, Fujimura Y, Tamura Y, Omata N, Kondo H, Moriya S, Furuya H, Kato M, Kojima H, Kashiwase K, Saji H, Khor S-S, Yamasaki M, Hirataka A, Ishigooka J, Wada Y, Chiba S, Yamada N, Okawa M, Kuroda K, Kume K, Hirata K, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, and Tokunaga K. An association analysis of HLA-DQB1 gene in Japanese narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time. Hum Genome Var 2: 15031, 2015.
  • Liu X, Kawashima M, Miyagawa T, Otowa T, Latt KZ, Thiri M, Nishida H, Sugiyama T, Tsurusaki Y, Matsumoto N, Mabuchi A, Tokunaga K, and Sasaki T. Novel rare variations of oxytocin receptor (OXTR) gene in autism spectrum disorder individuals. Hum Genome Var 2: 15024, 2015.
  • Jinam TA, Kanzawa-Kiriyama H, Inoue I, Tokunaga K, Omoto K, and Saitou N. Unique characteristics of the Ainu population in Northern Japan. J Hum Genet 60(10): 565-571, 2015.
  • Ueta M, Tokunaga K, Sotozono C, Sawai H, Yoon KC, Kim MK, Seo KY, Joo CK, Tashiro K, and Kinoshita S. HLA-A*02:06 and PTGER3 polymorphism exerts additive effects in cold medicine-related Stevens Johnson syndrome with severe ocular complications. Hum Genome Var 2: 15023, 2015.
  • Aiba Y, Yamazaki K, Nishida N, Kawashima M, Hitomi Y, Komori A, Kubo M, Tokunaga K, and Nakamura M. Shared disease-susceptibility genes between primary biliary cirrhosis and Crohn's disease in the Japanese population. J Hum Genet 60(9): 525-531, 2015.
  • Toyoda H, Miyagawa T, Koike A, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Imai M, Fujimura Y, Tamura Y, Ikwgami A, Wada Y, Moriya S, Furuya H, Takeuchi M, Kirino Y, Meguro A, Remmers EF, Kawamura Y, Otowa T, Miyashita A, Kashiwase K, Khor SS, Yamasaki M, Kuwano R, Sasaki T, Ishigooka J, Kuroda K, Kume K, Chiba S, Yamada N, Okawa M, Hirata K, Mizuki N, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, and Tokunaga K. A polymorphism in CCR1/CCR3 is associated with narcolepsy. Brain Behav Immun 49: 148-155, 2015.
  • Tamura M, Isojima T, Kawashima M, Yoshida H, Yamamoto K, Kitaoka T, Namba N, Oka A, Ozono K, Tokunaga K, and Kitanaka S. Detection of hereditary 1,25-hydroxyvitamin D-resistant rickets caused by uniparental disomy of chromosome 12 using genome-wide single nucleotide polymorphism array. PLoS ONE 10(7): e0131157, 2015.
  • Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor SS, Kashiwase K, Sugaya N, KawamuraY, Umekage T, Kojima H, Saji H, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H , Tokunaga K, and Sasaki T. Immune-related pathways including HLA-DRB1*13:02 are associated with panic disorder. Brain Behav Immun 46: 96-103, 2015.
  • Okamoto K, Honda K, Doi K, Ishizu T, Katagiri D, Wada T, Tomita K, Ohtake T, Kaneko T, Kobayashi S, Nangaku M, Tokunaga K, and Noiri E: Glypican-5 increases susceptibility to nephrotic damage in diabetic kidney. Am J Pathol 185(7): 1889-98, 2015.
  • Hitomi Y, Kawashima M, Aiba Y, Nishida N, Matsuhashi M, Okazaki H, Nakamura M, and Tokunaga K. Human primary biliary cirrhosis susceptible allele of rs4979462 enhances TNFSF15 expression by binding NF-1. Hum Genet 134(7): 737-747, 2015.
  • Ueta M, Sawai H, Sotozono C, Hitomi Y, Kaniwa N, Kim MK, Seo KY, Yoon KC, Joo CK, Kannabiran C, Wakamatsu TH, Sangwan V, Rathi V, Basu S, Ozeki T, Mushiroda T, Sugiyama E, Maekawa K, Nakamura R, Aihara M, Matsunaga K, Sekine A, Gomes JÁP, Hamuro J, Saito Y, Kubo M, Kinoshita S, and Tokunaga K. IKZF1, a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvements. J Allergy Clin Immunol 135(6): 1538-1545, 2015.
  • Miyagawa T, Toyoda H, Hirataka A, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Imai M, Fujimura Y, Tamura Y, Ikegami A, Wada Y, Moriya S, Furuya H, Kato M, Omata N, Kojima H, Kashiwase K, Saji H, Khor SS, Yamasaki M, Wada Y, Ishigooka J, Kuroda K, Kume K, Chiba S, Yamada N, Okawa M, Hirata K, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, and Tokunaga K: New susceptibility variants to narcolepsy identified in HLA class II region. Hum Mol Genet 24(3): 891-8, 2015.
  • Miyadera H, Ohashi J, Lernmark Å, Kitamura T, and Tokunaga K: Cell surface MHC density profiling reveals instability of autoimmunity-associated HLA. J Clin Invest 125(1): 275-91, 2015.
  • Iio E, Matsuura K, Nishida N, Maekawa S, Enomoto N, Nakagawa M, Sakamoto N, Yatsuhashi H, Kurosaki M, Izumi N, Hiasa Y, Masaki N, Ide T, Hino K, Tamori A, Honda M, Kaneko S, Mochida S, Nomura H, Nishiguchi S, Okuse C, Itoh Y, Yoshiji H, Sakaida I, Yamamoto K, Watanabe H, Hige S, Matsumoto A, Tanaka E, Tokunaga K, and Tanaka Y: Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C. Hum Genet 134(3): 279-89, 2015.
  • Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, and Iwata N: Genetic overlap between antipsychotic response and susceptibility to schizophrenia. J Clin Psychopharmacol 35(1): 85-8, 2015.

2014年

  • Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Okamoto A, Kono H, Tokunaga K, Takasaki Y, Hashimoto H, Sumida T, Tohma S, and Tsuchiya N: Association of functional polymorphisms in interferon regulatory factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study. PLoS ONE 9(10): e109764, 2014.
  • Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, Katayama S, Mori K, Yoneya S, Kohda M, Okazaki Y, Maruyama T, Shimada A, Yasuda K, Nishida N, Tokunaga K, and Koike A: A genome-wide association study for diabetic retinopathy in a Japanese population: potential association with a long intergenic non-coding RNA. PLoS ONE 9(11): e111715, 2014.
  • Srilohasin P, Chaiprasert A, Tokunaga K, Nishida N, Prammananan T, Smittipat N, Mahasirimongkol S, Chaiyasirinroje B, Yanai H, and Palittapongarnpimh P: Genetic Diversity and Dynamic Distribution of Mycobacterium tuberculosis Isolates Causing Pulmonary and Extrapulmonary Tuberculosis in Thailand. J Clin Microbiol 52(12): 4267- 4274, 2014.
  • Oda K, Uto H, Kumagai K, Ido A, Kusumoto K, Shimoda K, Hayashi K, Stuver SO, Tanaka Y, Nishida N, Tokunaga K, and Tsubouchi H. Impact of a single nucleotide polymorphism upstream of the IL28B gene in patients positive for anti-HCV antibody in an HCV hyperendemic area in Japan. J Med Virol 86(11): 1877-1885, 2014.
  • Ueta M, Kannabiran C, Wakamatsu TH, Kim MK, Yoon K-C, Seo KY, Joo C-K, Sangwan V, Rathi V, Basu S, Shamaila A, Lee HS, Yoon S, Sotozono C, Gomes JAP, Tokunaga K, and Kinoshita S. Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. Sci Rep 4: e5981, 2014.
  • Srilohasin P, Chaiprasert A, Tokunaga K, Nishida N, and Prammananan T. A novel DNA chip based on modified DigiTag2 assay for high throughput species identification and genotyping of Mycobacterium tuberculosis complex. J Clin Microbiol 52(6): 1962-1968, 2014.
  • Yamasaki M, Miyagawa T, Toyoda H, Khor SS, Koike A, Nitta A, Akiyama K, Sasaki T, Honda M, and Tokunaga K. Genome-wide analysis of CNV (copy number variation) and their associations with narcolepsy in a Japanese population. J Hum Genet 59(5): 235-240, 2014.
  • Ueta M, Kaniwa N, Sotozono C, Tokunaga K, Saito Y, Sawai H, Miyadera H, Sugiyama E, Maekawa K, Nakamura R, Nagato M, Aihara M, Matsunaga K, Takahashi Y, Furuya H, Muramatsu M, Ikezawa Z, and Kinoshita S: Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement. Sci Rep 4: e4862, 2014.
  • Takezawa Y, Kato K, Oota H, Caulfied T, Fujimoto A, Honda S, Kamatani N, Kawamura S, Kimura R, Matsumae H, Saito A, Savage P, Seguchi N, Shimizu K, Terao S, Yamaguchi-Kabata Y, Yasukouchi A, Yoneda M, and Tokunaga K: Human genetic research, race, ethnicity and the labeling of populations: recommendations based on an interdisciplinary workshop in Japan. BMC Med Ethics 15(1): e33, 2014.
  • Miura K, Mishima H, Kinoshita A, Hayashida C, Abe S, Tokunaga K, Masuzaki H, Yoshiura KI. Genome-wide association study of HPV-associated cervical cancer in Japanese women. J Med Virol 86(7): 1153-1158, 2014.
  • Nishino J, Sugiyama M, Nishida N, Tokunaga K, Mizokami M, and Mano S. The SNP x age interaction on response to interferon-α and ribavirin therapy in hepatitis C woman patients. J Med Virol 86(7): 1130-1133, 2014.
  • Yang JO, Hwang S, Kim WY, Park SJ, Kim SC, Park K, Lee B; HUGO Pan-Asian SNP Consortium: Identification of ethnivally specific genetic variations in pan-asian ethnos. Genomics Inform 12(1) 42-47, 2014.
  • Tokunaga k: Lessons from genome-wide search for disease-related genes with special reference to HLA-disease associations. Genes 5(1): 84-96, 2014.
  • Aiba Y, Harada K, Komori A, Ito M, Shimoda S, Nakamura H, Nagaoka S, Abiru S, Migita K, Ishibashi H, Nakanuma Y, Nishida N, Kawashima M, Tokunaga K, Yatsuhashi H, Nakamura M: Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis. Liver Int 34(5):679-688, 2014.
  • Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; RACI consortium; GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506(7488): 376-381, 2014.
  • Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JH, Hige S, Ide T, Yamamoto K, Sakaida I, Murawaki Y, Itoh Y, Tamori A, Orito E, Hiasa Y, Honda M, Kaneko S, Mita E, Suzuki K, Hino K, Tanaka E, Mochida S, Watanabe M, Eguchi Y, Masaki N, Murata K, Korenaga M, Mawatari Y, Ohashi J, Kawashima M, Tokunaga K, Mizokami M: New Susceptibility and Resistance HLA-DP Alleles to HBV-Related Diseases Identified by a Trans-Ethnic Association Study in Asia. PLoS One 9(2):e86449, 2014.
  • Sakakibara E, Takizawa R, Nishimura Y, Kawasaki S, Satomura Y, Kinoshita A, Koike S, Marumo K, Kinou M, Tochigi M, Nishida N, Tokunaga K, Eguchi S, Yamasaki S, Natsubori T, Iwashiro N, Inoue H, Takano Y, Takei K, Suga M, Yamasue H, Matsubayashi J, Kohata K, Shimojo C, Okuhata S, Kono T, Kuwabara H, Ishii-Takahashi A, Kawakubo Y, Kasai K: Genetic influences on prefrontal activation during a verbal fluency task in adults: a twin study based on multichannel near-infrared spectroscopy. Neuroimage 85 Pt 1:508-17, 2014.

2013年

  • Jinam TA, Phipps ME, Saitou N; HUGO Pan-Asian SNP Consortium: Admixture patterns and genetic differentiation in Negrito groups from West Malaysia estimated from genome-wide SNP data. Hum Biol 85(1-3): 173-188, 2013.
  • Isogai H, Miyadera H, Ueta M, Sotozono C, Kinoshita S, Tokunaga K, Hirayama N: In Silico Risk Assessment of HLA-A*02:06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients. J Toxicol 2013:514068, 2013.
  • Kanazawa T, Ikeda M, Glatt SJ, Tsutsumi A, Kikuyama H, Kawamura Y, Nishida N, Miyagawa T, Hashimoto R, Takeda M, Sasaki T, Tokunaga K, Koh J, Iwata N, Yoneda H: Genome-wide association study of atypical psychosis. Am J Med Genet B Neuropsychiatr Genet 162B(7):679-86, 2013.
  • Kawamura Y, Takahashi T, Liu X, Nishida N, Tokunaga K, Ukawa K, Noda Y, Yoshikawa A, Shimada T, Umekage T, Sasak T: DNA polymorphism in the FKBP5 gene affects impulsivity in intertemporal choice. Asia Pac Psychiatry 5(1):31-8, 2013.
  • Khor SS, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E, Tokunaga K: Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. PeerJ 1:e66, 2013.
  • Ikeda M, Okahisa Y, Aleksic B, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Sora I, Iyo M, Hashimoto R, Kawamura Y, Nishida N, Miyagawa T, Takeda M, Sasaki T, Tokunaga K, Ozaki N, Ujike H, Iwata N: Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. Neuropsychopharmacology 38(10):1864-70, 2013
  • Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I; Alzheimer Disease Genetics Consortium, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R: SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One 8(4):e58618, 2013.
  • Miyagawa T, Kawamura H, Obuchi M, Ikesaki A, Ozaki A, Tokunaga K, Inoue Y, Honda M: Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. PLoS One 8(1):e53707, 2013.
  • Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Matsuura K, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Tokunaga K, Mizokami M, Izumi N: Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C. J Med Virol 85(3):449-58, 2013
  • Hotta K, Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Nakao K, Sekine A: Replication study of 15 recently published Loci for body fat distribution in the Japanese population. J Atheroscler Throm 20(4):336-50, 2013.

2012年

  • Jinam TA, Hong LC, Phipps ME, Stoneking M, Ameen M, Edo J; HUGO Pan-Asian SNP Consortium, and Saitou N: Evolutionary history of continental Southeast Asians: "early train" hypothesis based on genetic analysis of mitochondrial and autosomal DNA data. Mol Biol Evol 29(11): 3513-27, 2012.
  • Koganebuchi K, Katsumura T, Nakagome S, Ishida H, Kawamura S, Oota H, and The Asian Archival DNA Repository Consortium: Autosomal and Y-chromosomal STR markers reveal a close relationship between Hokkaido Ainu and Ryukyu islanders. Anthrop Sci 120(3): 199-208, 2012.
  • Hitomi Y, Adachi T, Tsuchiya N, Honda Z, Tokunaga K, Tsubata T: Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. BMC Immunol 13:72, 2012.
  • Otowa T, Kawamura Y, Nishida N, Sugaya N, Koike A, Yoshida E, Inoue K, Yasuda S, Nishimura Y, Liu X, Konishi Y, Nishimura F, Shimada T, Kuwabara H, Tochigi M, Kakiuchi C, Umekage T, Miyagawa T, Miyashita A, Shimizu E, Akiyoshi J, Someya T, Kato T, Yoshikawa T, Kuwano R, Kasai K, Kato N, Kaiya H, Tokunaga K, Okazaki Y, Tanii H, Sasaki T: Meta-analysis of genome-wide association studies for panic disorder in the Japanese population. Transl Psychiatry 22:e186, 2012.
  • Japanese Archipelago Human Population Genetics Consortium, Jinam T, Nishida N, Hirai M, Kawamura S, Oota H, Umetsu K, Kimura R, Ohashi J, Tajima A, Yamamoto T, Tanabe H, Mano S, Suto Y, Kaname T, Naritomi K, Yanagi K, Niikawa N, Omoto K, Tokunaga K, Saitou N: The history of human populations in the Japanese Archipelago inferred from genome-wide SNP data with a special reference to the Ainu and the Ryukyuan populations. J Hum Genet 57(12):787-95, 2012.
  • Dinu I, Mahasirimongkol S, Liu Q, Yanai H, El-Din NS, Kreiter E, Wu X, Jabbari S, Tokunaga K, and Yasui Y: SNP-SNP interactions discovered by logic regression explain Crohn's disease genetics. PLoS ONE 7(10): e43035, 2012.
  • Kawashima M, Ohashi J, Nishida N, and Tokunaga K: Evolutionary Analysis of Classical HLA Class I and II Genes Suggests That Recent Positive Selection Acted on DPB1*04∶01 in Japanese Population. PLoS ONE 7(10): e46806, 2012.
  • Kumar V, Yi Lo PH, Sawai H, Kato N, Takahashi A, Deng Z, Urabe Y, Tokunaga K, Tanaka Y, Sugiyama M, Mizokami M, Muroyama R, Tateishi R, Omata M, Koike K, Tanikawa C, Kamatani N, Kubo M, Nakamura Y, and Matsuda K: Soluble MICA and a MICA variation as possibl prognostic biomarkers for HBV-induced hepatocellular carcinoma. PLoS ONE 7(9): e44743, 2012.
  • Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, and Ishibashi H: Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in Japanese. Am J Hum Genet 91(4): 721-728, 2012.
  • Okamoto K, Iwasaki N, Doi K, Noiri E, Iwamoto Y, Uchigata Y, Fujita T, and Tokunaga K: Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes mellitus. Diabetes 61(7): 1734-1741, 2012.
  • Erhardt A, Akula N, Schumacher J, Czamara D, Karbalai N, Mu ̈ller-Myhsok B, Mors O, Borglum A, Kristensen AS, Woldbye DPD, Koefoed P, Eriksson E, Maron E, Metspalu A, Nurnberger J, Philibert RA, Kennedy J, Domschke K, Reif A, Deckert J, Otowa T, Kawamura Y, Kaiya H, Okazaki Y, Tanii H, Tokunaga K, Sasaki T, Ioannidis JPA, McMahon FJ, and Binder EB: Replication and meta-analysis of TMEM132D gene variants in panic disorder. Transl Psychiatry 2: e156, 2012.
  • Ueta M, Tokunaga K, Sotozono C, Sawai H, Tamiya G, Inatomi T, and Kinoshita S: HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in stevens-Johnson syndrome with severe ocular surface complications. PLoS ONE 7(8): e43650, 2012.
  • Sawai H, Nishida N, Mbarek H, Matsuda K, Mawatari Y, Yamaoka M, Hige S, Kang J H, Abe K, Mochida S, Watanabe M, Kurosaki M, Asahina Y, Izumi N, Honda M, Kaneko S, Tanaka E, Matsuura K, Itoh Y, Mita E, Korenaga M, Hino K, Murawaki Y, Hiasa Y, Ide T, Ito K, Sugiyama M, Sang Ahn S H, Han K H, Park J Y, Yuen M F, Nakamura Y, Tanaka Y, Mizokami M and Tokunaga K: No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations. BMC Med Genet 13(1): 47, 2012.
  • Takamoto M, Kaburaki T, Mabuchi A, Araie M, Amano S, Aihara M, Tomidokoro A, Iwase A, Mabuchi F, Kashiwagi K, Shirato S, Yasuda N, Kawashima H, Nakajima F, Numaga J, Kawamura Y, Sasaki T, and Tokunaga K: Common variants on chromosome 9p21 are associated with normal tension glaucoma. PLoS ONE 7(7): e40107, 2012.
  • Nishida N, Sawai H, Matsuura K, Sugiyama M, Ahn SH, Park JY, Hige S, Kang JH, Suzuki K, Kurosaki M, Asahina Y, Mochida S, Watanabe M, Tanaka E, Honda M, Kaneko S, Orito E, Itoh Y, Mita E, Tamori A, Murawaki Y, Hiasa Y, Sakaida I, Korenaga M, Hino K, Ide T, Kawashima M, Mawatari Y, Sageshima M, Ogasawara Y, Koike A, Izumi N, Han K, Tanaka Y, Tokunaga K, and Mizokami M: Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. PLoS ONE 7(6): e39175, 2012.
  • Mahasirimongkol S, Yanai H, Mushiroda T, Promphittayarat W, Wattanapokayakit S, Promjai J, Yuliwulandari R, Wichukchinda N, Yowang A, Yamada N, Kantipong P, Takahashi A, Kubo M, Sawanpanyalert P, Kamatani N, Nakamura Y, and Tokunaga K: Genomic-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis. J Hum Genet 57(6): 363-367, 2012.
  • Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, and Kinoshita S: Epistatic interaction between Toll-ike receptor (TLR3) and prostaglandin E receptor 3 (PTGER3) genes. J Allergy Clin Immunol 129(5): 1413-1416, 2012.
  • Okamoto K, Iwasaki N, Doi K, Noiri E, Iwamoto Y, Uchigata Y, Fujita T, and Tokunaga K: Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes mellitus. Diabetes 61(7): 1734-1741, 2012.
  • Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl E, Kurreman F, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthigton J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, and Yamamoto K: Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 44(5): 511-517, 2012.
  • Sapkota BR, Hijikata M, Matsushita I, Tanaka G, Ieki R, Kobayashi N, Toyota E, Nagai H, Kurashima A, Tokunaga K, and Keicho N: Association of SLC11A1 (NRAMP1) polymorphisms with pulmonary Mycobacterium avium complex (MAC) infection. Hum Immunol 73(5): 529-536, 2012.
  • Hijikata M, Shojima J, Matsushita I, Tokunaga K, Ohashi J, Hang NT, Horie T, Sakurada S, Hoang NP, Thuong PH, Lien LT, and Keicho N: Association of IFNGR2 gene polymorphisms with pulmonary tuberculosis among the Vietnamese. Hum Genet 131(5): 675-682, 2012.
  • He Y, Wang WR, Xu S, Jin L, and Pan-Asia SNP Consortium: Paleolithic Contingent in Modern Japanese: Estimation and inference using genome-wide data. Sci Rep 2: e355, 2012.
  • Xu S, Pugach I, Stoneking M, Kayser M, Jin L, and HUGO Pan-Asia SNP Consortium: Genetic dating indicates that the Asian-Papuan admixture through Eastern Indonesia corresponds to the Austronesian expansion. Proc Natl Acad Sci USA 109(12): 4574-4579, 2012.
  • Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A, Takanashi M, Satake M, Nakajima K, Parham P, Arase H, Tokunaga K, Patarapotikul J, and Yabe T: Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. PLoS Pathogens 8(3): e1002565, 2012.
  • Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung U, and Kawaguchi H: C/EBpβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. Hum Mol Genet 21(5): 1111-1123, 2012.
  • Kobayashi K, Yuliwulandari R, Yanai H, Naka I, Lien L, Hang NTL, Hijikata M, Keicho N, and Tokunaga K: Association study of TLR polymorphisms with development of tuberculosis. Tissue Antigens 79(3): 190-197, 2012.
  • Shimogiri T, Nishida† N, Kudo M, K. Niwa K, Nishibori M, Kinoshita K, Okamoto S, Maeda Y, Tokunaga K, and Yasue H: Genetic relationships between Japanese native and commercial breeds using 70 chicken autosomal SNP genotypes by the DigiTag2 assay. Anim Genet 43(1): 98-103, 2012.
  • Nishida N, Mawatari Y, Sageshima M, and Tokunaga K: Highly parallel and short-acting amplification with locus-specific primers to detect single nucleotide polymorphisms by the DigiTag2 assay. PLoS ONE 7(1): e29967, 2012.
  • Ohnishi Y, Totoki Y, Toyoda A, Watanabe T, Yamamoto Y, Tokunaga K, Sakaki Y, Sasaki H, and Hohjoh H: Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development. Mol Biol Rep 39(2): 903-909, 2012.
  • Sugihara S, Ogata T, Kawamura T, Urakami T, Takemoto K, Kikuchi N, Takubo N, Tsubouchi K, Horikawa R, Kobayashi K, Kasahaera Y, Kikuchi T, Koike A, Mochizuki T, Minamitani K, Takaya R, Mochizuki H, Nishii A, Yokota I, Kizaki Z, Mori T, Shimura N, Mukai T, Matsuura N, Fujisawa T, Ihara K, Kosaka K, Kizu R, Takahashi T, Matsuo S, Hanaki K, Igarashi Y, Sasaki G, Soneda S, Teno S, Kanzaki S, Saji H, Tokunaga K, Amemiya, S, The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT): HLA-class II and class I genotypes among Japanese children with Type1A diabetes and their families. Pediatr Diabetes 13(1): 33-44, 2012.

2011年

  • Yang X, Xu S, The HUGO Pan-Asian SNP Consortium, Indian Genome Variation Consortium: Identification of close relatives in the HUGO Pan-Asian SNP database. PLoS ONE 6(12): e29502, 2011.
  • Kawamura Y, Otowa T, Koike A, Sugaya N, Yoshida E, Yasuda S, Inoue K, Takei K, Konishi Y, Tanii H, Shimada T, Tochigi M, Kakiuchi C, Umekage T, Liu X, Nishida N, Tokunaga K, Kuwano R, Okazaki Y, Kaiya H, and Sasaki T: A genome-wide CNV association study on panic disorder in a Japanese population. J Hum Genet 56(12): 852-856, 2011.
  • Ogoshi K, Hashimoto SI, Nakatani Y, Qu W, Oshima K, Tokunaga K, Sugano S, Hattori M, Morishita S, and Matsushima K: Genome-wide profiling of DNA methylation in human cancer cells. Genomics 98(4): 280-287, 2011
  • Kobayashi K, Yuliwulandari R, Yanai H, Lien LT, Hang NTL, Hijikata M, Keicho N, and Tokunaga K : Association between CD209 and development of tuberculosis in Indonesian and Vietnamese populations. Hum Immunol 72(9): 741-745, 2011.
  • Tanaka Y, Kurosaki M, Nishida N, Sugiyama M, Matsuura N, Sakamoto N, Enomoto N, Yatsuhashi H, NIshiguchi S, Hino K, Hige S, Itoh Y, Tanaka E, Mochida S, Honda M, Hiasa Y, Koike A, Sugauchi F, Kaneko S, Izumi N, Tokunaga K, and Mizokami M: Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C. Hum Mol Genet 20(17): 3507-3516, 2011.
  • Kurosaki M, Tanaka Y, Tanaka K, Suzuki Y, Hoshioka Y, Tamaki N, Kato T, Yasui Y, Hosokawa T, Ueda K, Tsuchiya K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Asahina Y, Matsuura K, Sugauchi F, Enomoto N, Nishida N, Tokunaga K, Mizokami M, and Izumi N: Relationship between polymorphisms of the inosine triphosphatase gene and anaemia or outcome after treatment with pegylated interferon and ribavirin. Antivir Ther 16(5): 685-694, 2011.
  • Kurotaki N, Tasaki S, Mishima H, Ono S, Imamura A, Kikuchi T, Nishida N, Tokunaga K, Yoshiura K, and Ozawa H: Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis. PLoS ONE 6(5): e20589, 2011.
  • Okamoto K, Tokunaga K, Doi, K, Fujita T, Suzuki H, Katoh T, Watanabe T, Nishida N, Mabuchi A, Takahashi A, Kubo M, Maeda S, Nakamura Y, and Noiri E: Common variation in GPC5 is associated with acquired nephrotic syndrome. Nat Genet 43(5): 459-463, 2011.
  • Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Hige S, Ito Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, and Watanabe M: Association of IL28B polymorphism with response pegylated-interferon alpha plus ribavirin combination therapy in patients with chronic genotype 2 hepatitis C. J Med Virol 83(5): 871-878, 2011.
  • Koike A, Nishida N, Yamashita D, and Tokunaga K: Comparative analysis of copy number variation detection methods and database construction. BMC Genetics 12: e29, 2011.
  • Miyagawa T, Miyadera H, Tanaka S, Kawashima M, Shimada M, Honda Y, Tokunaga K and Honda M: Abnormally low serum acylcarnitine level in narcolepsy. Sleep 34(3): 349-353A, 2011.
  • Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M: Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. J Hepatol 54(3): 439-448, 2011.
  • Otowa T, Kawamura Y, Sugaya N, Yoshida E, Shimada T, Liu X, Tochigi M, Umekage T, Miyagawa T, Nishida N, Kaiya H, Okazaki Y, Tokunaga K, and Sasaki T: Association study of PDE4B with panic disorder in the Japanese population. Prog. Neuropsychopharmacol. Biol Psychiatry 35(2): 545-549, 2011.
  • Hijikata M, Matsushita I, Tanaka G, Tsushiya T, Ito H, Tokunaga K, Ohashi J, Honma S, Kobashi Y, Taguchi Y, Azuma A, Kudoh S, and Keicho N*: Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis. Hum Genet 129(2): 117-128, 2011.
  • Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S,Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang] YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, and Mignot E: Common variants in P2RY11 are associated with narcolepsy. Nat Genet 43(1): 66-71, 2011.

2010年

  • Adachi S, Tajima A, Quan J, Haino K, Yoshihara K, Masuzaki H, Katabuchi H, Ikuma K, Suginami H, Nishida N, Kuwano R, Okazaki Y, Kawamura Y, Sasaki T, Tokunaga K, Inoue I, and Tanaka K: Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population. J Hum Genet 55(12): 816-21, 2010.
  • Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, and Watanabe M: ITPA gene variant protects against anemia induced by pegylated interferon-α andribavirin therapy for Japanese patients with chronic hepatitis C. Hepatol Res 40(11):1063-1071, 2010.
  • Ohnishi Y, Totoki Y, Toyoda A, Watanabe T, Yamamoto Y. Tokunaga K, Sakaki Y, Sasaki H, and Hohjoh H*: Small RNA class transition from siRNA/piRNA to miRNA during pre-implantaion mouse development. Nucleic Acids Res 38(15): 5141-5151, 2010.
  • Toyoda H, Tanaka S, Miyagawa T, Honda Y, Tokunaga K, and Honda M: Anti-tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy. Sleep 33(7): 875-878, 2010.
  • Yuliwulandari R, Sachrowardi Q, Nakajima F, Kashiwase K, Hirayasu K, Mabuchi A, Salam A M, and Tokunaga K*: Association of HLA-A, -B, and -DRB1 with pulmonary tuberculosis in western Javanese Indonesia. Hum Imunol 71(7): 697-701, 2010.
  • Shi L, Shi L, Yao YF, Matsushita M, Yu L, Huang XQ, Yi W, Oka T, Tokunaga K*, and Chu JY*: Genetic link among Hani, Bulang and other Southeast Asian populations: evidence from HLA -A, -B, -C, -DRB1 genes and haplotypes distribution. Int J Immunogenet 37(6): 467-75, 2010.
  • Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, and Kawaguchi H*: Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med 16(6): 678-686, 2010.
  • Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, OhkuboT, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Jun Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P on behalf of the Global BPgen consortium, Umemura S, Ueshima H, and Miki T: Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: The Japanese Millennium Genome Project. Hypertension 56(5): 973-980, 2010.
  • Ridruechai C, Mahasirimongkol S, Phromjai J, Yanai H, Nishida N, Matsushita I, Ohashi J, Yamada N, Moolphate S, Summanapan S, Chuchottaworn C, Manosuthi W, Kantipong P, Kanitvittaya S, Sawanpanyalert P, Keicho N, Khusmith S, and Tokunaga K*: Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. Genes Immun 11(5): 416-22, 2010.
  • Tanaka Y*, Nishida N, Sugiyama M, Tokunaga K, and Mizokami M: λ- Interferons and the single nucleotide polymorphisms: A mikestone to tailor-made therapy for chronic hepatitis C. Hepatol Res 40(5): 449-460, 2010.
  • Shimada M, Miyagawa T*, Kawashima M, Tanaka S, Honda Y, Honda M, and Tokunaga K: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Hum Genet 128(4): 433-441, 2010.
  • Yao Y, Shi L, Shi L, Kulski JK, Chen J, Liu S, Yu L, Lin K, Huang X, Tao Y, Tokunaga K*, and Chu J*: The association and differentiation of MHC class I polymorphic Alu insertions and HLA-B/Cw alleles in seven Chinese populations. Tissue Antigens 76(3): 194-207, 2010. Papers in 2011
  • Xu S, Kangwanpong D, Seielstad M, Srikummool M, Kampuansai J, Jin L, HUGO Pan-Asian SNP Consortium: Genetic evidence supports linguistic affinity of Mlabri?a hunter-gatherer group in Thailand. BMC Genet 11: e18, 2010.
  • Liu X, Kawamura Y, Shimada T, Otowa T, Koishi S, Sugiyama T, Nishida H, Hashimoto O, Nakagami R, Tochigi M, Umekage T, Kano Y, Miyagawa T, Kato N, Tokunaga K, and Sasaki T*: Association of the oxytocin receptor (OXTR) gene polymorphisms autism spectrum disorder (ASD) in Japanese population. J Hum Genet 55(3): 137-141, 2010.
  • Honda M*, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S, Hokuriku Liver Study Group: Hepatic ISG expression is associated with genetic variation in IL28B and the outcome of IFN therapy for chronic hepatitis C. Gastroenterology 139(2): 499-509, 2010.
  • Otowa T*, Tanii H, Sugaya N, Yoshida E, Inoue K, Yasuda S, Shimada T, Kawamura Y, Tochigi M, Minato T, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Okazaki Y, Kaiya H, and Sasaki T: Replication of a genome-wide association study of panic disorder in a Japanese population. J Hum Genet 55(2): 91-96, 2010.
  • Shi L, Yao Y, Shi L, Matsushita M, Yu L, Lin K, Tao Y, Oka T, Chu J*, and Tokunaga K*: HLA alleles and haplotypes distribution in Dai population in Yunnan Province, southwest of China. Tissue Antigens 75(2): 159-165, 2010.
  • Ebisawa T*, Numazawa K, Shimada H, Izutsu H, Sasaki T, Kato N, Tokunaga K, Mori A, Honma K, Honma S, and Shibata S: Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood. Neurosci Res 66(2): 223-227, 2010.
  • Okamoto K, Iwasaki N*, Nishimura C, Doi K, Noiri E, Nakamura S, Takizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, and Tokunaga K: Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Am J Hum Genet 86(1): 54-64, 2010.
  • Miyagawa T*, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y , and Tokunaga K: Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. J Hum Genet 55(1): 63-65, 2010.

2009年

  • HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC, Chaurasia A, Chen CH, Chen J, Chen YT, Chu J, Cutiongco-de la Paz EM, De Ungria MC, Delfin FC, Edo J, Fuchareon S, Ghang H, Gojobori T, Han J, Ho SF, Hoh BP, Huang W, Inoko H, Jha P, Jinam TA, Jin L*, Jung J, Kangwanpong D, Kampuansai J, Kennedy GC, Khurana P, Kim HL, Kim K, Kim S, Kim WY, Kimm K, Kimura R, Koike T, Kulawonganunchai S, Kumar V, Lai PS, Lee JY, Lee S, Liu ET*, Majumder PP, Mandapati KK, Marzuki S, Mitchell W, Mukerji M, Naritomi K, Ngamphiw C, Niikawa N, Nishida N, Oh B, Oh S, Ohashi J, Oka A, Ong R, Padilla CD, Palittapongarnpim P, Perdigon HB, Phipps ME, Png E, Sakaki Y, Salvador JM, Sandraling Y, Scaria V, Seielstad M, Sidek MR, Sinha A, Srikummool M, Sudoyo H, Sugano S, Suryadi H, Suzuki Y, Tabbada KA, Tan A, Tokunaga K, Tongsima S, Villamor LP, Wang E, Wang Y, Wang H, Wu JY, Xiao H, Xu S, Yang JO, Shugart YY, Yoo HS, Yuan W, Zhao G, Zilfalil BA, Indian Genome Variation Consortium: Mapping human genetic diversity in Asia. Science 326(5959): 1541-1545, 2009.
  • Kawabata Y, Ikegami H*, Awata T, Imagawa A, Maruyama T, Kawasaki E, Tanaka S, Shimada A, Osawa H, Kobayashi T, Hanafusa T, Tokunaga K, and Makino H: Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly-progessive and acute-onset type 1 diabetess. Diabetologia 52(12): 2513-2521. 2009.
  • Naka I, Patarapotikul J, Tokunaga K, Hananantachai H, Tsuchiya N, and Ohashi J*: A replication study of the association between the IL 12B promoter allel CTCTAA and susceptibility to cerebral malaria in Thai population. Malaria J 8: e290, 2009.
  • Naka I, Nishida N, Patarapotikul J, Nuchnoi P, Tokunaga K, Hananantachai H, Tsuchiya N, and Ohashi J*: Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria. Malaria J 8: e232, 2009.
  • Naka I, Patarapotikul J, Hananantachai H, Tokunaga K, Tsuchiya N, and Ohashi J*: IFNGR1 polymorphisms in Thai malaria patients. Infect Genet Evol 9(6): 1406-1409, 2009.
  • Hancks DC, Ewing AD, Chen JE, Tokunaga K, and Kazazian Jr HH*: Exon-trapping mediated by the human retrotransposon SVA. Genome Res 19(11): 1983-1991, 2009.
  • Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, and Mizokami M*: Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 41(10): 1105-1109, 2009.
  • Koike A*, Nishida N, Inoue I, Tsuji S, and Tokunaga K: Genome-wide association database developed in the Japanese Integrated Database Project. J Hum Genet 54(9): 543-546, 2009.
  • Fujimoto A, Nishida N, Kimura R, Miyagawa T, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Tsunoda T, Tokunaga K, and Ohashi J*: FGFR2 is associated with hair thickness in Asian populations. J Hum Genet 54(8): 461-465, 2009.
  • Keicho N*, Itoyama S, Kashiwase K, Phi NC, Long HT, Ha LD, Ban VV, Hoa BK, Hang NT, Hijikata M, Sakurada S, Satake M, Tokunaga K, and Quy T: Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population. Hum Immunol 70(7): 527-531, 2009.
  • Ueta M, Matsushita M*, Sotozono C, Kinoshita S, and Tokunaga K: Identification of a novel HLA-B allele, HLA-B*5904. Tissue Antigens 73(6): 612-614, 2009.
  • Hallmayer J, Faraco J, Ling L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong S, Honda Y, Honda M, Hogl B, Longstreth WT, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erthardt C, Hesla PE, Poli F, Frauscher B, Jeong J-H, Lee S-P, Ton TGN, Kvale M, Kolesar L, Dobrovolna M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok P-Y, Risch N, and Mignot E*: Narcolepsy is strongly associated with the TCR alpha locus. Nat Genet 41(6): 708-711, 2009.
  • Miyagawa T*, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, and Tokunaga K: Polymorphism located between CPTIB and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). PLoS ONE 4(4): e5394, 2009.
  • Yao Y, Shi L, Shi L, Matsushita M, Yu L, Lin K, Tao Y, Huang X, Yi W, Oka T, Tokunaga K*, and Chu J*: Distribution of HLA-A, -B, -Cw and -DRB1 alleles and haplotypes in an isolated Han population in Southwest China. Tissue Antigens 73(6): 561-568, 2009.
  • Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, Osawa H, Furuta H, Ng MCY, Hirota Y, Mori H, Ido K, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Wang H, Tanahashi T, Nakamura N, Takeda J, Maeda E, Yamamoto K, Tokunaga K, Ma RCW, So W, Chan JCN, Kamatani N, Makino H, Nanjo K, Kadowaki T, and Kasuga M*: Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on eleven genes with strong evidence of the association. J Hum Genet 54(4): 236-241, 2009.
  • Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, and Okazaki Y*: Genome-wide association study of panic disorder in the Japanese population. J Hum Genet 54(2): 122-126, 2009.
  • Yuliwulandari R, Kashiwase K, Nakajima H, Uddin J, susmirsih TP, Sofro A, and Tounaga K*: Polymorphisms of HLA genes in Western Javanse (Indonesia): Close affinities to southern groups of East Asian. Tissue Antigens 573(1): 46-53, 2009.
  • Vollstedt S, Yuliwulandari R, Okamoto K, Lien LT, Kicho N, Rochani JT, Wikaningrum R, and Tokunaga K*: No evidence for association between the interferon regulatory factor 1(IRF1) gene and clinical tuberculosis. Tuberculosis 89(1): 71-6, 2009.
  • Mahasirimongkol S, Yanai H, Nishida N, Ridruechai C, Matsushita I, Ohashi J, Summanapan S, Yamada N, Moolphate S, Chuchotaworn C, Chapraser A, Manosuthi W, Kantipong P, Kantiwaittaya S, Sura T, Khusmith S, Tokunaga K, Sawanpanyaleert P, and Keicho N*: Genome-wide SNP-based linkage analysis of tuberculosis in Thais. Genes Immun 10(1): 77-83, 2009.

2008年

  • Teeranaipong P, Ohashi J*, Patarapotikul J, Kimura R, Nuchonoi P, Hananantachai H, Naka I, Putaporntip C, Jongwutiwes S, and Tokunaga K: A functional SNP in the CR1 promoter region contributes to protection against cerebral Malaria. J. Infect Dis. 198(12): 1880-1891, 2008.
  • Miyagawa T, Kawashima M, Nishida N, Ohashi J, Kimura R, Fujimoto A, Shimada M, Morishita S, Shigeta T, Lin L, Hong SC, Faraco J, Shin YK, Jeong JH, Okazaki Y, Tsuji S, Honda M, Honda Y, Mignot E, and Tokunaga K*: Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nat. Genet. 40(11): 1324-1328, 2008.
  • Nishida N*, Koike A, Tajima A, Ogasawara Y, Ishibashi Y, Uehara Y, Inoue I, and Tokunaga K: Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals. BMC Genomics 9: e431, 2008.
  • Yoshikawa A, Shimada H, Numazawa K, Sasaki T, Ikeda M, Kawashima M, Kato N, Tokunaga K, and Ebisawa T*: Establishment of human cell lines showing circadian rhythms of bioluminescence. Neuroscience Letters 446: 40-44, 2008.
  • Naka I, Ohashi J*, Nuchnoi P, Hananantachai H, Looareesuwan S, Tokunaga K, and Patarapotikul J: Lack of association of the HbE variant with protection from cerebral malaria in Thailand. Biochem. Genet. 46(11-12): 708-711, 2008.
  • Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MCY, Ma RCW, So WY,Chan JCN, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, and Kasuga M*: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat. Genet. 40(9): 1092-1097, 2008.
  • Fujimoto A, Ohashi J*, Nishida N, Miyagawa T, Morishita Y, Tsunoda T, Kimura R, and Tokunaga K: A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia. Hum. Genet. 124(2): 179-185, 2008.
  • Shiota S, Tochigi M, Ohashi J, Kasai K, Kato N, Tokunaga K, and Sasaki T*: Association and interaction analyses of NRH1 and FRBB4 genes with schizophrenia in a Japanese population. J. Hum. Genet. 53(10): 929-935, 2008.
  • Miyagawa T, Nishida N, Kimura R, Fujimoto A, Kawashima M, Sasaki T, Tanii H, Otowa T, Momose Y, Nakahara Y, Okazaki Y, Tsuji S, and Tokunaga K*: Appropriate data cleaning method for genome-wide association study. J. Hum. Genet. 53(10): 886-893, 2008.
  • Hikami K, Ehara Y, Hasegawa M, Fujimoto M, Matsushita M, Oka T, Takehara K, Sato S, Tokunaga K, and Tsuchiya N*: Association of lL-10 Receptor 2 (lL10RB) with systemic sclerosis. Biochem. Biophys. Res. Commun. 373: 403-407, 2008.
  • Nakatsuji N*, Nakjima F, and Tokunaga K: HLA-haplotype banking and iPS cells. Nat. Biotech. 26(7): 739-740, 2008.
  • Nuchnoi P, Ohashi J*, Naka I, Nacapunchai D, Tokunaga K, Nishida N, and Patarapotikul J: Linkage disequilibrium structure of the 5q31-33 region in Thai. J. Hum. Genet. 53(9): 850-856, 2008.
  • Kimura R*, Ohashi J, Matsumura Y, Nakazawa M, Inaoka T, Ohtsuka R, and Tokunaga K: Gene flow and natural selection in Oceania: Inference from genome-wide SNP typing. Mol. Biol. Evol. 25(8): 1750-1761, 2008.
  • Ohnishi Y, Tamura Y, Yoshida M, Tokunaga K, and Hohjoh H*: Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi. PLoS ONE. 3(5): e2248, 2008.
  • Horikawa Y, Miyake K, Yasuda K, Enya M, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, and Kasuga M: Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J. Clin. Endocrinol. Metab. 93(8): 3136-3141, 2008.
  • Hirayasu K, Ohashi J, Tanaka H, Kashiwase K, Ogawa A, Takanashi M, Satake M, Jia GJ, Chimge N-O, Sideltseva E, Tokunaga K, and Yabe T*: Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class l in Northeast Asians. Am. J. Hum. Genet. 8(5):1075-108, 2008.
  • Mamegano K, Kuroki K, Miyashita R, Kusaoi M, Kobayashi S, Matsuta K, Maenaka K, Colonna N, Ozaki S, Hshimoto H, Takasaki Y, Tokunaga K, and Tsuchiya N*: Association of LILRA2 (ILT1, lIR7) splice site polymorphism with systemic lupus erytematosus and microscopic polyangiitis. Genes Immun. 9(3):214-23, 2008.
  • Nuchnoi P, Ohashi J*, Kimura R, Hananantachai H, Naka I, Krudsood S, Looareesuwan S, Tokunaga K, and Patarapotikul J*: Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. Ann. Hum. Genet. 72(3):327-36, 2008.
  • Mashimo Y, Suzuki Y, Hatori K, Tabara Y, Miki T, Tokunaga K, Katsuya T, Ogihara T, Yamada M, Takahashi N, Makita Y, Nakayama T, Soma M, Hirawa N, Umemura S, Ohkubo T, Imai Y, and Hata A: Assocaition of TNFRSF4 gene polymorphisms with essential hypertension. J. Hypertens. 26(5): 902-913, 2008.
  • Ueta M*, Tokunaga K, Sotozono C, Inatomi T, Yabe T, Matsushita M, Mitsuishi Y, and Kinoshita S: HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese. Mol. Vis. 14: 550-555, 2008
  • Yuliwulandari R, Sachrowardi Q, Nishida N, Takasu M, Batubara L, Susmiarsih TP, Rochabi JT, Wikaningrum R, Miyashita R, Miyagawa T, Sofro ASM, and Tokunaga K*: Polymorphisms of Promoter and Coding Regions of the Arylamine N-Acetyltransferase 2 (NAT2) Gene in the Indonesian Population: Proposal for a New Nomenclature. J. Hum. Genet. 53(3): 201-209, 2008.
  • Fujimoto A, Kimura R*, Ohashi J, Omi K, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Furusawa T, Nakazawa M, Ohtsuka R, and Tokunaga K: A scan for genetic determinants of human hair morphology: EDAR is associataed with Asian hair thickness. Hum. Mol. Genet. 17(6): 835-843, 2008.
  • Kawasaki A, Kyogoku C, Ohashi J, Miyashita R, Hikami K, Kusaoi M, Tokunaga K, Takahashi Y, Hashimoto H, Behrens TW, and Tsuchiya N*: Association of interferon regulatory factor 5 (IRF5) polymorphisms with systemic lupus erytematosus in Japanese: Support for a crucial role of intron 1 polymorphisms. Arth. Rheum. 58(3): 826-834, 2008.
  • Miyake K, Horikawa Y, Hara K, Yasuda K, Osawa H, Furuta H, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Makino H, Nanjo K, Kadowaki T, and Kasuga M*: Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J. Hum. Genet. 53(2): 174-180, 2008.
  • Kohara K*, Tabara Y, Nakura J, Imai Y, Ohkubo T, Hata A, Soma M, Nakayama T, Umemura S, Hirawa N, Ueshima H, Kita Y, Ogihara T, Katsuya T, Takahashi N, Tokunaga K, and Miki T: Systemic multiple candidate gene approach for identification of susceptible genes and susceptible pathways for hypertension: a millennium genome project for hypertension. Hypertens. Res. 31(2): 203-212, 2008
  • Omi K, Hachiya NS, Tanaka M, Tokunaga K, and Kaneko K*: 14-3-3 zeta is indispensable for the aggregate formation with polyglutamine- expanded huntingtin protein. Neurosci. Lett. 431(1): 45-50, 2008.
  • Yabe T*, Matsuo K, Hirayasu K, Kashiwase K, Kawamura-Ishii S, Tanaka H, Ogawa A, Takanashi M, Satake M, Nakajima K, Tokunaga K, Inoko H, Saji H, Ogawa S, Juji T, Sasazuki T, Kodera Y, and Morishima Y: Donor killer immunoglobulin-like receptor(KIR) genotype-patient cognate KIR ligand combination and anti-thymocyte globulin pre-administration are critical factors in outcome of HLA-C-KIR ligand mismatched T cell-replete unrelated bone marrow transplantation. Bio. Blood Marrow Transplant. 14(1): 75-87, 2008.

2007年

  • Nakano K, Sakai N, Yamazaki Y, Watanabe H, Yanada N, Sezaki K, Sugami T, Tokunaga K, Takato T, and Uchinuma E: Novel mutations of the HOXD13 gene in hand and foot malformations. Int. Surg. 92(5): 287-295, 2007.
  • Doi K, Noiri E, Maeda R, Nakao A, Kobayashi S, Tokunaga K, and Fujita T: Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients. Hypertens. Res. 30(12): 1193-1198, 2007
  • Shi L, Ogata S, Yu JK, Ohashi J, Yu L, Shi L, Sun H, Lin K, Huang XQ, Matushita M, Horai S, Muramatsu M, Chu JY*, and Tokunaga K*: Distribution of HLA alleles and haplotypes in Jinuo and Wa populations in Southwest China. Hum. Immunol. 69(1): 58-65, 2007.
  • Hoa B.K., Hang N.T.L., Kashiwase K, Ohashi J, Lien L.T., Horie J, Shojima J, Hijikata M, Satake M, Tokunaga K, Sasazuki N, and Keicho K*: HLA-A, B, C, DRB1 and DQB1 alleles and haplotaypes in the Kinh population in Vietnam. Tissue Antigens 71: 127-134, 2007.
  • Ohashi J*, Naka I, Kimura R, Natsuhara K, Yamauchi T, Furusawa T, Nakazawa M, Ataka Y, Patarapotikul J, Nuchnoi P, Tokunaga K, Ishida T, Inaoka T, Matsumura Y, and Ohtsuka R: FTO polymorphisms in Oceanic populations. J. Hum. Genet. 52(12): 1031-1035, 2007.
  • Takasu M, Hayashi R, Maruya E, Ota M, Imura M, Kougo K, Kobayashi C, Saji H, Ishikawa Y, Asai T, and Tokunaga K*: Deletion of entire HLA-A gene accompanied by an insertion of a retrotransposon. Tissue Antigens 70(2): 144-150, 2007.
  • Mai HN, Hijikata M, Inoue Y, Suzuki K, Sakatani M, Okada M, Kimura K, Kobayashi N, Toyota E, Kudo K, Nagai H, Kurashima A, Kajiki A, Oketani N, Hayakawa H, Tanaka G, Shojima J, Matsushita I, Sakurada S, Tokunaga K, and Keicho N*: Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 of the CFTR gene. Int. J. Tubers. Lung Dis. 11(7):808-813, 2007.
  • Kimura R, Fujimoto A, Tokunaga K, and Ohashi J: A practical genome scan for population-specific strong selective sweeps that have reached fixation. PLoS ONE. 2: e286, 2007.
  • Naka I, Ohashi J, Patarapotikul J, Hananantachai H, Wilaiatana P, Looareesuwan S, and Tokunaga K: The genotype of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria. J. Hum. Genet. 52(5): 476-9, 2007. Nishida N*, Tanabe T, Takasu M, Suyama A, and Tokunaga K: Further development of multiplex SNP typing method, DigiTag2 assay. Anal. Biochem. 364: 78-85, 2007.
  • Kawasaki A, Tsuchiya N*, Ohashi J, Murakami Y, Fukazawa T, Kusaoi M, Morimoto S, Matsuta K, Hashimoto H, Takasaki Y, and Tokunaga K: Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erytematosus in Japanese. Rheumatology 46(5): 776-782, 2007.
  • Hananantachai H, Patarapotikul J, Ohashi J*, Naka I, Looareesuwan S, and Tokunaga K: Significant association between TNF-a (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand. Tissue Antigens 69(3): 277-280, 2007.
  • Tochigi M, Zhang X, Ohashi J, Hibino H, Otowa T, Rogers M, Kato T, Okazaki Y, Kato N, Tokunaga K, Sasaki T: Association study between the TNXB locus and schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet. 144(3): 305-309, 2007.
  • Hitomi Y, Tsuchiya N*, Hasegawa M, Fujimoto M, Takehara K, Tokunaga K, and Sato S: Association of CD22 gene polymorphism with susceptibility to limited cutaneous systemic sclerosis. Tissue Antigens 69(3): 242-249, 2007.
  • Ogata S, Shi L, Matsushita M, Yu L, Huang XQ, Shi L, Sun H, Ohashi J, Muramatsu M, Tokunaga K*, Chu JY*: Polymorphisms of HLA genes in Maonan people in China. Tissue Antigens 69(2): 154-160, 2007.
  • Ueta M, Sotozono C, Tokunaga K, Yabe T, and Kinoshita S: Strong association between HLA-A*0206 and Stevens-Johnson syndrome in Japanese. Am. J. Ophthalmol. 143(2): 367-368, 2007.

2006年

  • Ohashi J*, Naka I, Kimura R, Tokunaga K, Nakazawa M, Ataka Y, Ohtsuka R, Inaoka T, and Matsumura Y: HLA-DRB1 polymorphism on Ha'ano Island of the Kingdom of Tonga. Anthrop. Sci. 114(3): 193-198, 2006.
  • Nakajima F, Tokunaga K*, and Nakatsuji N*: HLA matching estimations in a hyprothetical bank of human embryonic stem cell lines in the Japanese population for use in cell transplantation therapy. Stem Cells 25(4): 983-985, 2006.
  • Ohashi J*, Naka I, Toyoda A, Takasu M, Tokunaga K, Ishida T, Sakaki Y, and Hohjoh H: Estimation of the species-specific mutation rates of the DRB1 locus in human and chimpanzee. Tissue Antigens 68(5): 427-431, 2006.
  • Tochigi M, Zhang X, Ohashi J, Hibino H, Otowa T, Rogers M, Kato T, Okazaki Y, Kato N, Tokunaga K, and Sasaki T*: Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population. Neurosci. Res. 56(2): 154-158, 2006.
  • Ohashi J*, Naka I, Tokunaga K, Inaoka T, Ataka Y, Nakazawa M, Matsumura Y, and Ohtsuka R: Mitochondrial DNA variation suggests extensive gene flow from Polynesian ancestors to indigenous Melanesians in the northwestern Bismarck. Am. J. Phys. Anthrop. 130(4): 551-556, 2006.
  • Kawashima M, Tamiya G, Oka A, Hohjoh H, Juji T, Ebisawa T, Honda Y, Inoko H, and Tokunaga K*: Genome-wide association analysis of human narcolepsy and a new resistance gene. Am. J. Hum. Genet. 79(2): 252-263. 2006.
  • Vu HA, Xinh PT, Masuda M, Motoji T, Toyoda A, Sakaki Y, Tokunaga K, and Sato Y*: FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation. Leukemia. 20(8): 1414-1421, 2006.
  • Shiina T*, Ota M, Shimizu S, Katsuyama Y, Hashimoto N, Takasu M, Anzai T, Kulski J, Kikkawa E, Naruse T, Kimura N, Yanagiya K, Watanabe A, Hosomichi K, Kohara S, Iwamoto C, Umehara K, Meyer A, Wanner V, Sano K, Macquin C, Ikeo K, Tokunaga K, Gojobori T, Inoko H, and Bahram S: Rapid evolution of MHC class l genes in primates generates new disease alleles in man via Hitchhiking diversity. Genetics 173(3): 1555-1570, 2006.
  • Xinh PT, Vu HA, Van Man H, Tri NK, Binh NT, Nghia H, Trong PQ, Van Binh T, Van Be T, Tokunaga K, Sato Y*: Unique secondary chromosomal abnormalities are frequently found in the chronic phase of chronic myeloid leukemia in southern Vietnam. Cancer Genet Cytogenet. 168(1): 59-68, 2006.
  • Ohnishi Y, Tokunaga K, Kaneko K, and Hohjoh H*: Assessment of allele-specific gene silencing by RNA interference with mutant and wide-type reporter alleles. J RNAi Gene Silencing 2(1): 154-160, 2006.
  • Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Tobe K, Nagai R, Kadowaki T*: Hepatocyte nuclear factor-4{alpha} P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population. Diabetes 55(5): 1260-1264, 2006.
  • Noguchi E*, Ohtsuki Y, Tokunaga K, Yamaoka-Sageshima M, Ichikawa K, Aoki T, Shibasaki M, Arinami T (2006) ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population. Clin. Exp. Allergy 36(5): 602-608
  • Ohashi J*, Naka I, Kimura R, Tokunaga K, Yamauchi T, Natsuhara K, Furusawa T, Yamamoto R, Nakazawa M, Ishida T, and Ohtsuka R (2006) Polymorphisms in the ABO blood group in three population in New Georgia Islands, Solomon Islands. J. Hum. Genet. 51(5): 407-411
  • Sato-Takeda M, Takasaki I, Takeda K, Sasaki A, Andoh T, Nojima H, Shiraki K, Kuraishi Y, Hanaoka K, Tokunaga K, and Yabe T* (2006) Major histocompatibility complex haplotype is associated with postherpetic pain in mice. Anesthesiology 104(5): 1063-1069
  • Horikoshi M, Hara K, Ohashi J, Miyake K, Tokunaga K, Ito C, Kasuga M, Nagai R, and Kadowaki T* (2006) A polymorphism In the AMPKa2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population. Diabetes 55(4): 919-923
  • Hirayasu K, Ohashi J, Kashiwase K, Takanashi M, Satake M, Tokunaga K, and Yabe T* (2006) Long-term persistence of both functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection. Hum. Genet. 119(4): 436-443
  • Doi K, Noiri E*, Fujita T, and Tokunaga K (2006) No-association of VEGF genetic polymorphisms in promoter - 5' UTR with end-stage renal disease. Nephrol. Dial. Transplant. 21(4): 1124-1125
  • Miyashita R, Tsuchiya N*, Yabe T, Kobayashi S, Hashimoto H, Ozaki S, and Tokunaga K (2006) Association of killer cell immunoglobulin-like receptor (KIR) genotypes with microscopic polyangiitis. Arthritis Rheum. 54(3): 992-997
  • Doi K, Noiri E*, Nakao A, Fujita T, Kobayashi S, Tokunaga K (2006) Functional polymorphisms in the vascular endothelial growth factor gene are associated with development of end-stage renal disease in males. J. Am. Soc. Nephrol. 17(3): 823-830
  • Yoshiura K*, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko V, Alipov G, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N, Mapendano C, Ghandami M, Nomura M, Liang DS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A, Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, Murray J, Saito S, Nakamura Y, and Niikawa N (2006) A SNP in the ABCC11 gene is the determinant of human earwax type. Nature Genet. 38(3): 324-330
  • Shi L, Xu SB, Ohashi J, Sun H, Yu JK, Huang XQ, Tao YF, Yu L, Horai S, Chu JY*, and Tokunaga K* (2006) HLA-A, B and DRB1 alleles and haplotypes in Naxi and Han populations in southwestern China (Yunnan province). Tissue Antigens 67(1): 38-44 Xinh PT, Vu HA, Nghia H, Binh NT, Be TV, Binh TV, Tokunaga K, and Sato Y*: (2006) Coexistence of Philadelphia chromosome positive cells with and without der(9) deletion in a patient with chronic myelogenous leukemia. Cancer Genet. Cytogenet. 164(2): 122-127

2005年以前

  • Tsuchiya N*, Kobayashi S, Hashimoto H, Ozaki S, and Tokunaga K (2005) Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangitis in Japanese. Genes Immun. 7(1): 81-84
  • Doi K, Noiri E*, Nakao A, Fujita T, Kobayashi S, and Tokunaga K (2005) Haplotype analysis of NAD(P)H oxidase p22 phox polymorphisms in end-stage renal disease. J. Hum. Genet 50(12): 641-647
  • Nishida N*, Tanabe T, Hashido K, Hirayasu K, Takasu M, Suyama A, and Tokunaga K (2005) DigiTag assay for multiplex SNP typing with high success rate. Anal. Biochem. 3
  • Omi K, Hachiya NS, Tokunaga K, and Kaneko K* (2005) SiRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro. Biochem. Biophys. Res. Commun : 338(2): 1229-1235
  • Watanabe M, Kobayashi K, Jin F, Park KS, Yamada T, Tokunaga K, and Toda T* (2005) Founder SVA retrotransposal insertion in Fukuyama-type congenital muscular dystrophy and its origin in Japanese and Northeast Asian populations. Am. J. Med. Genet. A 138(4): 344-348
  • Kono H, Kyogoku C, Suzuki T, Tsuchiya N, Honda H, Yamamoto K, Tokunaga K, and Honda Z* (2005) FcgRIIB lle232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreased affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hum. Mol. Genet. 14(19): 2881-2892
  • Ohashi J*, Naka I, Patarapotikul J, Hananantachai H, Tangpukdee N, Looareesuwan S, and Tokunaga K (2005) A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. Malaria J. 4: 38
  • Van PNT, Xinh PT, Kano Y, Tokunaga K, and Sato Y* (2005) Establishment and characterization of a novel Philadelphia-chromosome positive chronic myeloid leukemia cell line, TCC-S, expressing P210 and P190 BCR/ABL transcripts but missing normal ABL gene. Hum. Cell 18(1): 25-33
  • Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, and Kadowaki T* (2005) Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. Diabetologia 48(7): 1307-1314
  • Kuroki K, Tsuchiya N*, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, Fukazawa T, Kusaoi M, Murakami Y, Takiguchi M, Juji T, Hashimoto H, Kohda D, Maenaka K, and Tokunaga K (2005) Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum. Mol. Genet. 14(16): 2469-2480
  • Ohashi J*, Naka I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan S, Clark AG, and Tokunaga K (2005) Strong linkage disequilibrium of a HbE variant with the (AT)9(T)5 repeat in the BP1 binding site upstream of the β-globin gene in Thai population. J. Hum. Genet. 50: 7-11
  • Hananantachai H, Patarapotikul J, Ohashi J*, Naka I, Looareesuwan S, and Tokunaga K (2005) Polymorphisms of HLA-B and HLA-DRB1 genes in Thai malaria patients. Jpn. J. Infect. Dis. 58(1): 25-28
  • Ohnishi Y, Tokunaga K, and Hohjoh H* (2005) Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3'- or 5'-end of the sense-stranded siRNA element. Biochem. Biophys. Res. Commun. 329(2): 516-21
  • Tanaka G, Matsushita I, Ohashi J, Tsuchiya N, Ikushima S, Oritus M, Hijikata M, Nagata T, Yamamoto K, Tokunaga K, and Keicho N* (2005) Evaluation of microsatellite makers in association studies: a search for an immune-related susceptibility gene in sarcoidosis. Immunogenet. 56(12): 861-70
  • Noguchi E*, Yokouchi Y, Zhang J, Shibuya K, Shibuya A, Bannai M, Tokunaga K, Doi H, Tamari M, Shimizu M, Shirakawa T, Shibasaki M, Ichikawa K, and Arinami T (2005) Positional identification of an asthma susceptibility gene on human chromosome 5q33. Am. J. Respir. Crit. Care Med. 172(2): 183-188
  • Nam MH, Hijikata M, Tuan LA, Lien LT, Shojima J, Horie T, Nakata K, Matsushita I, Ohashi J, Tokunaga K, and Keicho N* (2005) Variations of the CFTR gene in the Hanoi-Vietnamese. Am. J. Med Genet A. 136(3): 249-253
  • Vu HA, Xinh PT, Kikushima M, Zhu Y, Tokuhara M, Tani M, Shimizu T, Saito K, Tokunaga K, Sato Y* (2005) A recurrent duodenal gastrointestinal stromal tumor with a frameshift mutation resulting in a stop codon in KIT exon 13. Genes Chromosomes Cancer 42:179-83
  • Hase H, Kanno Y, Kojima M, Hasegawa K, Sakurai D, Kojima H, Tsuchiya N, Tokunaga K, Masawa N, Azuma M, Okuma K, and Kobata T* (2004) BAFF/BlyS can potentinate B-cell selection with the B-cell co-receptor complex. Blood 103: 2257-2265
  • Tajima A, Hayami M, Tokunaga K, Juji T, Matsuo M, Marzuki S, Omoto K, and Horai S* (2004) Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages. J. Hum. Genet. 49(4): 187-193
  • Tochigi M, Zhang X, Umekage T, Ohashi J, Kato C, Marui T, Otowa T, Hibino H, Otani T, Kohda K, Liu S, Kato N, Tokunaga K, and Sasaki T* (2004) Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population. Am. J. Med. 128(B): 37-40
  • Sato-Takeda M, Ihn H, Ohashi J, Tsuchiya N, Ishikawa Y, Satake M, Arita H, Tamaki K, Hanaoka K, Tokunaga K, and Yabe T* (2004) The human histocompatibility leukocyte antigen (HLA) haplotype is associated with the onset of postherpetic neuralgia after herpes zoster. Pain 110: 329-336
  • Kamio K, Matsushita I, Ohashi J, Hijikata M, Nakata K, Tokunaga K, Kudoh S, and Keicho N* (2004) Direct determination of MUC5B promoter haplotypes based on the method of single-strand conformation polymorphism and their statistical estimation. Genomics 84(3): 613-622
  • Furuya T, Hakoda M, Tsuchiya N, Ichikawa N, Nanke Y, Nakajima A, Takeuchi M, Nishinarita M, Kondo H, Kawasaki A, Kobayashi S, Mimori T, Tokunaga K, and Kamatani N* (2004) Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy. J. Rheumatol. 9: 1768-1774
  • Sakurai D, Tsuchiya N*, Yamaguchi A, Okaji Y, Tsuno N.T, Kobata T, Takahashi K, and Tokunaga K (2004) Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells. J. Immunol. 173(9): 5801-5809
  • Ehara Y, Sakurai D, Tsuchiya N*, Nakano K, Tanaka Y, Yamaguchi A, and Tokunaga K (2004) Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. Clin. Exp. Rheumatol. 22(6): 707-712
  • Tsuchiya N*, Kuroki K, Fujimoto M, Murakami Y, Tedder TF, Tokunaga K, Takehara K, Sato S (2004) Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis. Arthritis Rheum 50:4002-7
  • Sakurai D, Tsuchiya N*, Yamaguchi A, Okaji Y, Tsuno NH, Kobata T, Takahashi K, Tokunaga K (2004) Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells. J Immunol 173:5801-9
  • Sago N, Omi K, Tamura Y, Kunugi H, Toyo-oka T, Tokunaga K, Hohjoh H* (2004) RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed. Biochem Biophys Res Commun 319:50-7
  • Omi K, Tokunaga K, Hohjoh H* (2004) Long-lasting RNAi activity in mammalian neurons. FEBS Lett 558:89-95
  • Ohashi J*, Naka I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan S, Clark AG, Tokunaga K (2004) Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. Am J Hum Genet 74:1198-208
  • Ohashi J*, Naka I, Ohtsuka R, Inaoka T, Ataka Y, Nakazawa M, Tokunaga K, Matsumura Y (2004) Molecular polymorphism of ABO blood group gene in Austronesian and non-Austronesian populations in Oceania. Tissue Antigens 63:355-61
  • Miyashita R, Tsuchiya N*, Hikami K, Kuroki K, Fukazawa T, Bijl M, Kallenberg CG, Hashimoto H, Yabe T, Tokunaga K (2004) Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. Int Immunol 16:163-8
  • Kyogoku C, Tsuchiya N*, Wu H, Tsao BP, Tokunaga K (2004) Association of Fcgamma receptor IIA, but not IIB and IIIA, polymorphisms with systemic lupus erythematosus: A family-based association study in Caucasians. Arthritis Rheum 50:671-3
  • Hitomi Y, Tsuchiya N*, Kawasaki A, Ohashi J, Suzuki T, Kyogoku C, Fukazawa T, Bejrachandra S, Siriboonrit U, Chandanayingyong D, Suthipinittharm P, Tsao BP, Hashimoto H, Honda Z, Tokunaga K (2004) CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B. Hum Mol Genet 13:2907-17
  • Doi K, Doi H, Noiri E, Nakao A, Fujita T, Tokunaga K* (2004) High-throughput single nucleotide polymorphism typing by fluorescent single-strand conformation polymorphism analysis with capillary electrophoresis. Electrophoresis 25:833-8
  • Chu ZT, Tsuchiya N*, Kyogoku C, Ohashi J, Qian YP, Xu SB, Mao CZ, Chu JY, Tokunaga K (2004) Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations. Tissue Antigens 63:21-7
  • Bannai M*, Higuchi K, Akesaka T, Furukawa M, Yamaoka M, Sato K, Tokunaga K (2004) Single-nucleotide-polymorphism genotyping for whole-genome-amplified samples using automated fluorescence correlation spectroscopy. Anal Biochem 327:215-21
  • Akesaka T, Lee SG, Ohashi J, Bannai M, Tsuchiya N, Yoon Y, Tokunaga K, Song K* (2004) Comparative study of the haplotype structure and linkage disequilibrium of chromosome 1p36.2 region in the Korean and Japanese populations. J Hum Genet 49:603-9
  • Xinh PT, Tri NK, Nagao H, Nakazato H, Taketazu F, Fujisawa S, Yagasaki F, Chen YZ, Hayashi Y, Toyoda A, Hattori M, Sakaki Y, Tokunaga K, Sato Y* (2003) Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1. Genes Chromosomes Cancer 36:313-6
  • Tsuchiya N*, Kobayashi S, Kawasaki A, Kyogoku C, Arimura Y, Yoshida M, Tokunaga K, Hashimoto H (2003) Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis. J Rheumatol 30:1534-40
  • Siriboonrit U, Tsuchiya N*, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Fujiwara K, Chandanayingyong D, Tokunaga K (2003) Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens 61:374-83
  • Omi K, Ohashi J*, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K (2003) CD36 polymorphism is associated with protection from cerebral malaria. Am J Hum Genet 72:364-74
  • Ohashi J*, Tokunaga K (2003) Power of genome-wide linkage disequilibrium testing by using microsatellite markers. J Hum Genet 48:487-91
  • Ohashi J*, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2003) A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand. Genes Immun4:528-31
  • Ohashi J*, Maruya E, Tokunaga K, Saji H (2003) Power of association test for detecting minor histocompatibility gene causing graft-versus-host disease following bone marrow transplantation [correction]. J Hum Genet 48:502-7
  • Kojima S, Hirose M, Tokunaga K, Sakaki Y, Tei H* (2003) Structural and functional analysis of 3' untranslated region of mouse Period1 mRNA. Biochem Biophys Res Commun 301:1-7
  • Hohjoh H*, Takasu M, Shishikura K, Takahashi Y, Honda Y, Tokunaga K (2003) Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics 4:151-3
  • Hohjoh H*, Ohashi J, Takasu M, Nishioka T, Ishida T, Tokunaga K (2003) Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species. Immunogenetics 54:856-61
  • Hikami K, Tsuchiya N*, Yabe T, Tokunaga K (2003) Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. Genes Immun 4:160-7
  • Tri NK, Xinh PT, Nagao H, Izumi T, Ozawa K, Toyoda A, Hattori M, Sakaki Y, Tokunaga K, Sato Y* (2002) Identification of the breakpoints at 1p36.2 and 3p21.3 in an AML(M3) patient who had t(1;3)(p36.2;p21.3) at the third relapse. Genes Chromosomes Cancer 35:365-7
  • Sirikong M, Tsuchiya N, Chandanayingyong D*, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002) Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens 59:113-7
  • Omi K, Ohashi J*, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K (2002) Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. Parasitol Int 51:361-6
  • Omi K, Ohashi J*, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K (2002) Absence of association between the Fc gamma receptor IIIA-176F/V polymorphism and the severity of malaria in Thai. Jpn J Infect Dis 55:167-9
  • Omi K, Ohashi J*, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2002) Polymorphisms of CD36 in Thai malaria patients. Southeast Asian J Trop Med Public Health 33 Suppl 3:1-4
  • Ohashi J*, Tokunaga K (2002) The expected power of genome-wide linkage disequilibrium testing using single nucleotide polymorphism markers for detecting a low-frequency disease variant. Ann Hum Genet 66:297-306
  • Ohashi J*, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2002) Significant association of longer forms of CCTTT Microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand. J Infect Dis 186:578-81
  • Ohashi J*, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2002) Lack of association between interleukin-10 gene promoter polymorphism, -1082G/A, and severe malaria in Thailand. Southeast Asian J Trop Med Public Health 33 Suppl 3:5-7
  • Lapteva N, Ide K, Nieda M, Ando Y, Hatta-Ohashi Y, Minami M, Dymshits G, Egawa K, Juji T, Tokunaga K* (2002) Activation and suppression of renin-angiotensin system in human dendritic cells. Biochem Biophys Res Commun 296:194-200
  • Kyogoku C, Tsuchiya N*, Matsuta K, Tokunaga K (2002) Studies on the association of Fc gamma receptor IIA, IIB, IIIA and IIIB polymorphisms with rheumatoid arthritis in the Japanese: evidence for a genetic interaction between HLA-DRB1 and FCGR3A. Genes Immun 3:488-93
  • Kyogoku C, Dijstelbloem HM, Tsuchiya N*, Hatta Y, Kato H, Yamaguchi A, Fukazawa T, Jansen MD, Hashimoto H, van de Winkel JG, Kallenberg CG, Tokunaga K (2002) Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum 46:1242-54
  • Kuroki K, Tsuchiya N*, Tsao BP, Grossman JM, Fukazawa T, Hagiwara K, Kano H, Takazoe M, Iwata T, Hashimoto H, Tokunaga K (2002) Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese. Genes Immun 3 Suppl 1:S21-30
  • Kawasaki A, Tsuchiya N*, Fukazawa T, Hashimoto H, Tokunaga K (2002) Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis. Genes Immun 3:424-9
  • Wakui M, Yamaguchi A, Sakurai D, Ogasawara K, Yokochi T, Tsuchiya N, Ikeda Y, Tokunaga K* (2001) Genes highly expressed in the early phase of murine graft-versus-host reaction. Biochem Biophys Res Commun 282:200-6
  • Tsuchiya N*, Kawasaki A, Tsao BP, Komata T, Grossman JM, Tokunaga K (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun 2:317-22
  • Sakurai D, Yamaguchi A, Tsuchiya N*, Yamamoto K, Tokunaga K (2001) Expression of ID family genes in the synovia from patients with rheumatoid arthritis. Biochem Biophys Res Commun 284:436-42
  • Ohashi J*, Yamamoto S, Tsuchiya N, Hatta Y, Komata T, Matsushita M, Tokunaga K (2001) Comparison of statistical power between 2 * 2 allele frequency and allele positivity tables in case-control studies of complex disease genes. Ann Hum Genet 65:197-206
  • Ohashi J*, Tokunaga K (2001) The power of genome-wide association studies of complex disease genes: statistical limitations of indirect approaches using SNP markers. J Hum Genet 46:478-82
  • Ohashi J*, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K (2001) Absence of association between the allele coding methionine at position 29 in the N-terminal domain of ICAM-1 (ICAM-1(Kilifi)) and severe malaria in the northwest of Thailand. Jpn J Infect Dis 54:114-6
  • Ogasawara K*, Yabe R, Uchikawa M, Nakata K, Watanabe J, Takahashi Y, Tokunaga K (2001) Recombination and gene conversion-like events may contribute to ABO gene diversity causing various phenotypes. Immunogenet 53:190-9
  • Lapteva N, Nieda M*, Ando Y, Nicol A, Ide K, Yamaura A, Hatta-Ohashi Y, Egawa K, Juji T, Tokunaga K (2001) Gene expression analysis in human monocytes, monocyte-derived dendritic cells, and alpha-galactosylceramide-pulsed monocyte-derived dendritic cells. Biochem Biophys Res Commun 289:531-8
  • Lapteva N, Nieda M*, Ando Y, Ide K, Hatta-Ohashi Y, Dymshits G, Ishikawa Y, Juji T, Tokunaga K* (2001) Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray. Biochem Biophys Res Commun 285:1059-65
  • Lapteva N, Ando Y, Nieda M, Hohjoh H, Okai M, Kikuchi A, Dymshits G, Ishikawa Y, Juji T, Tokunaga K* (2001) Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array. Br J Haematol 114:191-7
  • Komatsu-Wakui M, Tokunaga K*, Ishikawa Y, Leelayuwat C, Kashiwase K, Tanaka H, Moriyama S, Nakajima F, Park MH, Jia GJ, Chimge NO, Sideltseva EW, Juji T (2001) Wide distribution of the MICA-MICB null haplotype in East Asians. Tissue Antigens 57:1-8
  • Kawasaki A, Tsuchiya N*, Fukazawa T, Hashimoto H, Tokunaga K (2001) Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis. Genes Immun 2:276-9
  • Hohjoh H*, Tokunaga K (2001) Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter. Genes Immun 2:105-9
  • Hohjoh H*, Terada N, Nakayama T, Kawashima M, Miyagawa T, Honda Y, Tokunaga K (2001) Case-control study with narcoleptic patients and healthy controls who, like the patients, possess both HLA-DRB1*1501 and -DQB1*0602. Tissue Antigens 57:230-5
  • Hohjoh H*, Terada N, Miki T, Honda Y, Tokunaga K (2001) Haplotype analyses with the human leucocyte antigen and tumour necrosis factor-alpha genes in narcolepsy families. Psychiatry Clin Neurosci 55:37-9
  • Hohjoh H*, Terada N, Honda Y, Juji T, Tokunaga K (2001) Negative association of the HLA-DRB1*1502-DQB1*0601 haplotype with human narcolepsy. Immunogenetics 52:299-301
  • Hagiwara K, Yamaguchi A, Tsuchiya N*, Kitamura S, Iwadare J, Sahara R, Yamamoto K, Tokunaga K (2001) Identification of genes upregulated in the inflamed colonic lesions of Crohn's disease. Biochem Biophys Res Commun 283:130-5
  • Chida S, Hohjoh H*, Hirai M, Tokunaga K (2001) Haplotype-specific sequence encoding the protein kinase, interferon-inducible double-stranded RNA-dependent activator in the human leukocyte antigen class II region. Immunogenetics 52:186-94
  • Ohashi J, Tokunaga K (2000) Computer simulation analysis suggests weak balancing selection operative at the MICA locus. Hereditas 133(1):25-8.
  • Hikami K, Tsuchiya N, Tokunaga K (2000) New variations in human OX40 ligand (CD134L) gene. Genes Immun. 1(8):521-2
  • Tsuchiya N, Komata T, Matsushita M, Ohashi J, Tokunaga K (2000) New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus. Genes Immun. 1(8):501-3.
  • Hatta Y, Tsuchiya N, Ohashi J, Matsushita M, Fujiwara K, Hagiwara K, Juji T, Tokunaga K (2000) Association of Fc gamma receptor IIIB, but not of Fc gamma receptor IIA and IIIA polymorphisms with systemic lupus erythematosus in Japanese. Genes Immun. 1(1):53-60.
  • Kato H, Tsuchiya N, Tokunaga K (2000) Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. Genes Immun. 1(5):330-7.
  • Kawasaki A, Tsuchiya N, Hagiwara K, Takazoe M, Tokunaga K (2000) Independent contribution of HLA-DRB1 and TNF alpha promoter polymorphisms to the susceptibility to Crohn's disease. Genes Immun. 1(6):351-7.
  • Matsushita M, Tsuchiya N, Oka T, Yamane A, Tokunaga K (2000) New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. Genes Immun. 1(7):428-34.
  • Hohjoh H, Terada N, Kawashima M, Honda Y, Tokunaga K (2000) Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy. Tissue Antigens. 56(5):446-8.
  • Miyagawa T, Hohjoh H, Honda Y, Juji T, Tokunaga K (2000) Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy. Immunogenetics. 52(1-2):12-8.
  • Umino Y, Hohjoh H, Tokunaga K (2000) Novel single nucleotide polymorphisms (SNPs) at positions 497 (T/G) and 829 (T/C) in the human c-FOS gene and haplotype association. Hum Mutat. 16(3):279.
  • Shishikura K, Hohjoh H, Tokunaga K (2000) Novel allele containing a 190C>T nonsynonymous substitution in the N-acetyltransferase (NAT2) gene. Hum Mutat. 15(6):581.
  • Narita K, Sasaki T, Akaho R, Okazaki Y, Kusumi I, Kato T, Hashimoto O, Fukuda R, Koyama T, Matsuo K, Okabe Y, Nanko S, Hohjoh H, Tokunaga K (2000) Human leukocyte antigen and season of birth in Japanese patients with schizophrenia. Am J Psychiatry. 157(7):1173-5.
  • Ohashi J, Tokunaga K (2000) Sojourn times and substitution rate at overdominant and linked neutral loci. Genetics 155(2):921-7.
  • Ohashi J, Yoshida M, Ohtsuka R, Nakazawa M, Juji T, Tokunaga K (2000) Analysis of HLA-DRB1 polymorphism in the Gidra of Papua New Guinea. Hum Biol. 72(2):337-47.
  • Keicho N, Ohashi J, Tamiya G, Nakata K, Taguchi Y, Azuma A, Ohishi N, Emi M, Park MH, Inoko H, Tokunaga K, Kudoh S (2000) Fine localization of a major disease-susceptibility locus for diffuse panbronchiolitis. Am J Hum Genet. 66(2):501-7.
  • Kasai F, Takahashi E, Koyama K, Terao K, Suto Y, Tokunaga K, Nakamura Y, Hirai M (1999) Comparative FISH mapping of the ancestral fusion point of human chromosome 2. Chromosome Res. 8(8):727-35.
  • Kato H, Tsuchiya N, Izumi S, Miyamasu M, Nakajima T, Kawasaki H, Hirai K, Tokunaga K (1999) New variations of human CC-chemokine receptors CCR3 and CCR4. Genes Immun. 1(2):97-104.
  • Matsushita M, Tsuchiya N, Shiota M, Komata T, Matsuta K, Zama K, Oka T, Juji T, Yamane A, Tokunaga K (1999) Lack of a strong association of CTLA-4 exon 1 polymorphism with the susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese: an association study using a novel variation screening method. Tissue Antigens 54(6):578-84.
  • Hagiwara K, Tsuchiya N, Takazoe M, Yamamoto K, Tokunaga K (1999) Identification of the gene variations in human IKKA. Immunogenetics 50(5-6):363-5.
  • Matsushita M, Tsuchiya N, Nakayama T, Ohashi J, Shibue T, Shiota M, Oka T, Yamane A, Tokunaga K (1999) Allele typing of human TNFA 5'-flanking region using polymerase chain reaction-preferential homoduplex formation assay (PCR-PHFA): linkage disequilibrium with HLA class I and class II genes in Japanese. Tissue Antigens 54(5):478-84.
  • Chida S, Hohjoh H, Tokunaga K (1999) Molecular analyses of the possible RNA-binding protein gene located in the human leukocyte antigen (HLA)--DR subregion. Gene 15;240(1):125-32.
  • Hohjoh H, Takahashi Y, Hatta Y, Tanaka H, Akaza T, Tokunaga K, Honda Y, Juji T (1999) Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome. Psychiatry Clin Neurosci. 53(4):527-9.
  • Kuroki Y, Iwamoto T, Lee J, Yoshiike M, Nozawa S, Nishida T, Ewis AA, Nakamura H, Toda T, Tokunaga K, Kotliarova SE, Kondoh N, Koh E, Namiki M, Shinka T, Nakahori Y (1999) Spermatogenic ability is different among males in different Y chromosome lineage. J Hum Genet. 44(5):289-92.
  • Hohjoh H, Nakayama T, Ohashi J, Miyagawa T, Tanaka H, Akaza T, Honda Y, Juji T, Tokunaga K (1999) Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy. Tissue Antigens 54(2):138-45.
  • Anzai T, Naruse TK, Tokunaga K, Honma T, Baba H, Akazawa T, Inoko H (1999) HLA genotyping of 5,000- and 6,000-year-old ancient bones in Japan. Tissue Antigens 54(1):53-8.
  • Ohashi J, Tokunaga K (1999) Selecting a contingency table in a population-based association study: allele frequency or positivity? J Hum Genet. 44(4):246-8.
  • Shinka T, Tomita K, Toda T, Kotliarova SE, Lee J, Kuroki Y, Jin DK, Tokunaga K, Nakamura H, Nakahori Y (1999) Genetic variations on the Y chromosome in the Japanese population and implications for modern human Y chromosome lineage. J Hum Genet. 44(4):240-5.
  • Komata T, Tsuchiya N, Matsushita M, Hagiwara K, Tokunaga K (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens 53(6):527-33.
  • Matsushita M, Tsuchiya N, Oka T, Yamane A, Tokunaga K (1999) New variations of human SHP-1. Immunogenetics 49(6):577-9.
  • Hatta Y, Ohashi J, Imanishi T, Kamiyama H, Iha M, Simabukuro T, Ogawa A, Tanaka H, Akaza T, Gojobori T, Juji T, Tokunaga K (1999) HLA genes and haplotypes in Ryukyuans suggest recent gene flow to the Okinawa Islands. Hum Biol. 71(3):353-65.
  • Komatsu-Wakui M, Tokunaga K, Ishikawa Y, Kashiwase K, Moriyama S, Tsuchiya N, Ando H, Shiina T, Geraghty DE, Inoko H, Juji T (1999) Immunogenetics 49(7-8):620-8.
  • Keicho N, Tokunaga K, Nakata K, Taguchi Y, Azuma A, Tanabe K, Matsushita M, Emi M, Ohishi N, Kudoh S (1999) Contribution of TAP genes to genetic predisposition for diffuse panbronchiolitis. Tissue Antigens 53(4 Pt 1):366-73.
  • Emi M, Keicho N, Tokunaga K, Katsumata H, Souma S, Nakata K, Taguchi Y, Ohishi N, Azuma A, Kudoh S (1999) Association of diffuse panbronchiolitis with microsatellite polymorphism of the human interleukin 8 (IL-8) gene. J Hum Genet. 44(3):169-72.
  • Kotliarova SE, Toda T, Takenaka O, Matsushita I, Hida A, Shinka T, Goto J, Tokunaga K, Nakagome Y, Nakahori Y (1999) Novel (CA)n marker DXYS241 on the nonrecombinant part of the human Y chromosome. Hum Biol. 71(2):261-75.
  • Furukawa H, Yabe T, Akaza T, Tadokoro K, Tohma S, Inoue T, Tokunaga K, Yamamoto K, Geraghty DE, Juji T (1999) Cell surface expression of HLA-E molecules on PBMC from a TAP1-deficient patient. Tissue Antigens 53(3):292-5.
  • Yamashita T, Fujii T, Tokunaga K, Tadokoro K, Hamai Y, Miki A, Kozuma S, Juji T, Taketani Y (1999) Analysis of human leukocyte antigen-G polymorphism including intron 4 in Japanese couples with habitual abortion. Am J Reprod Immunol. 41(2):159-63.
  • Hatta Y, Tsuchiya N, Matsushita M, Shiota M, Hagiwara K, Tokunaga K (1999) Identification of the gene variations in human CD22. Immunogenetics 49(4):280-6.
  • Furukawa H, Murata S, Yabe T, Shimbara N, Keicho N, Kashiwase K, Watanabe K, Ishikawa Y, Akaza T, Tadokoro K, Tohma S, Inoue T, Tokunaga K, Yamamoto K, Tanaka K, Juji T (1999) Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome. J Clin Invest. 103(5):755-8.
  • Furukawa H, Kashiwase K, Yabe T, Ishikawa Y, Akaza T, Tadokoro K, Tohma S, Inoue T, Tokunaga K, Yamamoto K, Juji T (1998) Polymorphism of TAPASIN and its linkage disequilibria with HLA class II genes in the Japanese population. Tissue Antigens 52(3):279-81.
  • Miki A, Ishikawa Y, Yabe T, Furukawa H, Fujii T, Tokunaga K, Akaza T, Tadokoro K, Taketani Y, Juji T (1998) Human lymphocytes obtained from decidual tissue express killer activatory receptors as well as killer inhibitory receptors: analysis using a single strand conformation polymorphism method. Am J Reprod Immunol. 39(4):271-8.
  • Kobayashi K, Nakahori Y, Miyake M, Matsumura K, Kondo-Iida E, Nomura Y, Segawa M, Yoshioka M, Saito K, Osawa M, Hamano K, Sakakihara Y, Nonaka I, Nakagome Y, Kanazawa I, Nakamura Y, Tokunaga K, Toda T (1998) An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature 394(6691):388-92.
  • Kobayashi K, Nakahori Y, Mizuno K, Miyake M, Kumagai T, Honma A, Nonaka I, Nakamura Y, Tokunaga K, Toda T (1998) Founder-haplotype analysis in Fukuyama-type congenital muscular dystrophy (FCMD). Hum Genet. 103(3):323-7.
  • Keicho N, Tokunaga K, Nakata K, Taguchi Y, Azuma A, Bannai M, Emi M, Ohishi N, Yazaki Y, Kudoh S (1998) Contribution of HLA genes to genetic predisposition in diffuse panbronchiolitis. Am J Respir Crit Care Med. 158(3):846-50.
  • Bannai M, Tokunaga K, Tanaka H, Lin L, Kashiwase K, Tokunaga K, Juji T (1997) Five HLA-B22 group alleles in Japanese. Tissue Antigens 49(4):376-82.
  • Tokunaga K, Ishikawa Y, Ogawa A, Wang H, Mitsunaga S, Moriyama S, Lin L, Bannai M, Watanabe Y, Kashiwase K, Tanaka H, Akaza T, Tadokoro K, Juji T (1997) Sequence-based association analysis of HLA class I and II alleles in Japanese supports conservation of common haplotypes. Immunogenetics 46(3):199-205.
  • Suto Y, Yabe T, Maenaka K, Tokunaga K, Tadokoro K, Juji T (1997) The human natural killer gene complex (NKC) is located on chromosome 12p13.1-p13.2. Immunogenetics. 46(2):159-62.
  • Miyake M, Nakahori Y, Matsushita I, Kobayashi K, Mizuno K, Hirai M, Kanazawa I, Nakagome Y, Tokunaga K, Toda T (1997) YAC and cosmid contigs encompassing the Fukuyama-type congenital muscular dystrophy (FCMD) candidate region on 9q31. Genomics 40(2):284-93.
  • Toda T, Miyake M, Kobayashi K, Mizuno K, Saito K, Osawa M, Nakamura Y, Kanazawa I, Nakagome Y, Tokunaga K, Nakahori Y (1996) Linkage-disequilibrium mapping narrows the Fukuyama-type congenital muscular dystrophy (FCMD) candidate region to <100 kb. Am J Hum Genet. 59(6):1313-20.