業績 / Publication
Akihiro Fujimoto (Since July 2019)
- Yoshida-Tanaka K, Ikemoto K, Kuribayashi R, Unoki M, Takano T, Fujimoto A*: Long-read sequencing reveals the complex structure of extra dic(21;21) chromosome and its biological effects, Human Genetics: Online ahead of print (doi: 10.1007/s00439-023-02583-9)
- Unoki M*, Velasco G, Kori S, Arita K, Daigaku Y, Yeung WKA, Fujimoto A, Ohashi H, Kubota T, Miyake K, Sasaki H. Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation. Human Molecular Genetics, 2023 Apr 20;32(9):1439-1456
- Nishida N, Ohashi J, Suda G, Chiyoda T, Tamaki N, Tomiyama T, Ogasawara S, Sugiyama M, Kawai Y, Khor SS, Nagasaki M, Fujimoto A, Tsuchiura T, Ishikawa M, Matsuda K, Yano H, Yoshizumi T, Izumi N, Hasegawa K, Sakamoto N, Mizokami M, Tokunaga: Prediction Model with HLA-A*33:03 Reveals Number of Days to Develop Liver Cancer from Blood Test Int J Mol Sci. 2023 Mar 1;24(5):4761
- Ikemoto K, Fujimoto H, Fujimoto A*: Localized assembly for long reads enables genome-wide analysis of repetitive regions at single-base resolution in human genomes. Hum Genomics. 2023 Mar 9;17(1):21
- Gochi L, Kawai Y, Fujimoto A*: Comprehensive analysis of microsatellite polymorphisms in human populations. Hum Genet. 2023 Jan;142(1):45-57
- Yagasaki K, Mabuchi A, Higashino T, Hao Wong J, Nishida N, Fujimoto A, Tokunaga K: Practical forensic use of kinship determination using high-density SNP profiling based on a microarray platform, focusing on low-quantity DNA. Forensic Sci Int Genet. 2022 Nov;61:102752
- Kiyose H, Nakagawa H, Ono A, Aikata H, Ueno M, Hayami S, Yamaue H, Chayama K, Shimada M, Wong JH, Fujimoto A*: Comprehensive analysis of full-length transcripts reveals novel splicing abnormalities and oncogenic transcripts in liver cancer. PLoS Genet. 2022 Aug 4;18(8):e1010342
- Sano Y, Koyanagi Y, Wong JH, Murakami Y, Fujiwara K, Endo M, Aoi T, Hashimoto K, Nakazawa T, Wada Y, Ueno S, Gao D, Murakami A, Hotta Y, Ikeda Y, Nishiguchi KM, Momozawa Y, Sonoda KH, Akiyama M, Fujimoto A*: Likely pathogenic structural variants in genetically unsolved patients with retinitis pigmentosa revealed by long-read sequencing. J Med Genet. 2022 Nov;59(11):1133-1138
- Mizuno K, Sumiyoshi T, Okegawa T, Terada N, Ishitoya S, Miyazaki Y, Kojima T, Katayama H, Fujimoto N, Hatakeyama S, Shiota M, Yoshimura K, Matsui Y, Narita S, Matsumoto H, Kurahashi R, Kanno H, Ito K, Kimura H, Kamiyama Y, Sunada T, Goto T, Kobayashi T, Yamada H, Tsuchiya N, Kamba T, Matsuyama H, Habuchi T, Eto M, Ohyama C, Ito A, Nishiyama H, Okuno H, Kamoto T, Fujimoto A, Ogawa O, Akamatsu S. Clinical Impact of Detecting Low-Frequency Variants in Cell-Free DNA on Treatment of Castration-Resistant Prostate Cancer. Clin Cancer Res. 2021 Nov 15;27(22):6164-6173
- Mizuno S, Yamaguchi R, Hasegawa T, Hayashi S, Fujita M, Zhang F, Koh Y, Lee SY, Yoon SS, Shimizu E, Komura M, Fujimoto A, Nagai M, Kato M, Liang H, Miyano S, Zhang Z, Nakagawa H, Imoto S. Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories. Sci Rep. 2021 Aug 3;11(1):15713
- Ashouri S, Wong JH, Nakagawa H, Shimada M, Tokunaga K, Fujimoto A*: Characterization of intermediate-sized insertions using whole-genome sequencing data and analysis of their functional impact on gene expression. Hum Genet. 2021 Aug;140(8):1201-1216
- Fujimoto A*, Wong JH, Yoshii Y, Akiyama S, Tanaka A, Yagi H, Shigemizu D, Nakagawa H, Mizokami M, Shimada M. Whole-genome sequencing with long reads reveals complex structure and origin of structural variation in human genetic variations and somatic mutations in cancer. Genome Med. 2021 Apr 29;13(1):65
- Yokoe T, Kurozumi S, Nozawa K, Ozaki Y, Maeda T, Yazaki S, Onishi M, Fujimoto A, Nakayama S, Tsuboguchi Y, Iwasa T, Sakai H, Ogata M, Terada M, Nishimura M, Onoe T, Masuda J, Kurikawa M, Isaka H, Hagio K, Shimomura A, Okumura Y, Futamura M, Shimokawa M, Takano T. Clinical benefit of treatment after trastuzumab emtansine for HER2-positive metastatic breast cancer: a real-world multi-centre cohort study in Japan (WJOG12519B). Breast Cancer. 2021 May;28(3):581-591
- Tanaka A, Ishitsuka Y, Ohta H, Fujimoto A, Yasunaga JI, Matsuoka M. Systematic clustering algorithm for chromatin accessibility data and its application to hematopoietic cells. PLoS Comput Biol. 2020 Nov 30;16(11):e1008422
- Shibayama Y, Takahashi K, Yamaguchi H, Yasuda J, Yamazaki D, Rahman A, Fujimori T, Fujisawa Y, Takai S, Furukawa T, Nakagawa T, Ohsaki H, Kobara H, Wong JH, Masaki T, Yuzawa Y, Kiyomoto H, Yachida S, Fujimoto A, Nishiyama A. Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H. Commun Biol. 2020 Nov 27;3(1):724
- Dutta M, Nakagawa H, Kato H, Maejima K, Sasagawa S, Nakano K, Sasaki-Oku A, Fujimoto A, Mateos RN, Patil A, Tanaka H, Miyano S, Yasuda T, Nakai K, Fujita M. Whole genome sequencing analysis identifies recurrent structural alterations in esophageal squamous cell carcinoma. PeerJ. 2020 Jun 26;8:e9294
- Fujimoto A*, Fujita M, Hasegawa T, Wong JH, Maejima K, Oku-Sasaki A, Nakano K, Shiraishi Y, Miyano S, Yamamoto G, Akagi K, Imoto S, Nakagawa H. Comprehensive analysis of indels in whole-genome microsatellite regions and microsatellite instability across 21 cancer types. Genome Res. 2020 Mar 24;30(3):334-46
- Fujita M, Yamaguchi R, Hasegawa T, Shimadad S, Arihiroe K, Hayashi S, Maejima K, Nakano K, Fujimoto A, Ono A, Aikata H, Ueno M, Hayami S, Tanaka H, Miyano S, Yamaue H, Chayama K, Kakimi K, Tanaka S, Imoto S, Nakagawa H (2020) Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations. EBioMedicine 53:102659
- Fujimoto A*, Fujita M, Hasegawa T, Wong JH, Maejima K, Oku-Sasaki A, Nakano K, Shiraishi Y, Miyano S, Yamamoto G, Akagi K, Imoto S, and Nakagawa H (2020) Comprehensive Analysis of Indels in Whole-genome Microsatellite Regions and Microsatellite Instability across 21 Cancer Types. Genome Research 30:334–34
- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. (2020) Pan-cancer analysis of whole genomes. Nature 578: 82-93.
- Shimada M, Miyagawa T, Takeshima A, Kakita A, Toyoda H, Niizato K, Oshima K, Tokunaga K, and Honda M (2020) Epigenome-wide association study of narcolepsy-affected lateral hypothalamic brains, and overlapping DNA methylation profiles between narcolepsy and multiple sclerosis. Sleep 43.
- Mizuno K, Akamatsu S, Sumiyoshi T, Wong J1. Mizuno K, Akamatsu S, Sumiyoshi T, Wong JH, Fujita M, Maejima K, Nakano K, Ono A, Aikata H, Ueno M, Hayami S, Yamaue H, Chayama K, Inoue T, Ogawa O, Nakagawa H and Fujimoto A* (2019) eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA. Sci Rep 9: 15017
- Wong JH, Shigemizu D, Yoshii Y, Akiyama S, Tanaka A, Nakagawa H, Narumiya S, Fujimoto A* (2019) Identification of intermediate-sized deletions and inference of their impact on gene expression in a human population. Genome Medicine 11:44
Motoko Unoki (Since 2000)
- Yoshida-Tanaka K, Ikemoto K, Kuribayashi R, Unoki M, Takano T, Fujimoto A*: Long-read sequencing reveals the complex structure of extra dic(21;21) chromosome and its biological effects, Human Genetics: Online ahead of print (doi: 10.1007/s00439-023-02583-9)
- Uemura S, Maenohara S, Inoue K, Ogonuki N, Matoba S, Ogura A, Kurumizaka M, Yamagata K, Sharif J, Koseki H, Ueda K, Unoki M*, Sasaki H. UHRF1 is essential for proper cytoplasm architecture and function of mouse oocyte and derived embryo. Life Sci. Alliance, 6(8):e202301904, 2023
- Unoki M*, Velasco G, Kori S, Arita K, Daigaku Y, Yeung WKA, Fujimoto A, Ohashi H, Kubota T, Miyake K, Sasaki H. Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation. Human Molecular Genetics 32(9):1439-1456, 2023
- Unoki M*, Sasaki H: The UHRF protein family in epigenetics, development, and carcinogenesis (Review). Proceedings of the Japanese Academy, Ser. B, Physical and Biological Science 98(8): 401-415, 2022
- Velasco G, Ulveling D, Rondeau S, Marzin P, Unoki M, Cormier-Daire V, Francastel C: Interplay between histone and DNA methylation seen through comparative methylomes in rare mendelian disorders. International Journal of Molecular Sciences 22(7): 3735, 2021
- Unoki M*: Chromatin remodeling in replication-uncoupled maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studies (Review). Genes to Cells 26(6): 349-359, 2021
- Haratake N, Hu Q, Okamoto T, Jogo T, Toyokawa G, Kinoshita F, Takenaka T, Tagawa T, Iseda N, Itoh S, Yamada Y, Oda Y, Shimokawa M, Kikutake C, Suyama M, Unoki M, Sasaki H, Mori M: Identification of SLC38A7 as a prognostic marker and potentially targetable driver gene of lung squamous cell carcinoma. Annals of Surgery 274 (3): 500-507, 2021
- Morikawa T, Ohishi H, Kosaka, K, Shimojo T, Nagano A, Taniguchi I, Fujioka R, Moriyama K, Unoki M, Takahashi M, Nakao M, Izumi Y, Bamba T, Sasaki H, Miura S, Shibata H: Ddhd1 knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia. Bioscience Reports 41(2): BSR20204171, 2021
- Unoki M*, Sharif J, Saito Y, Velasco G, Francastel C, Koseki H, Sasaki H: CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats. Scientific Reports 10: 17865, 2020
- Ohishi H, Au Yeung WK, Unoki M, Ichiyanagi K, Fukuda K, Maenohara S, Shirane K, Chiba H, Sado T, Sasaki H: Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells. Genes to Cells 25(1): 54-64, 2020
- Kori S, Jimenji T, Ekimoto T, Sato M, Kusano F, Oda T, Unoki M, Ikeguchi M, Arita K: Serine 298 phosphorylation in linker 2 of UHRF1 regulates ligand-binding property of its tandem Tudor domain. Journal of Molecular Biology 432(14): 4061-4075, 2020
- Aktar S, Sasaki H, Unoki M*: Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation. Genes to Cells 24(11): 746-755, 2019
- Unoki M*, Funabiki H, Velasco G, Francastel C, Sasaki H: CDCA7 and HELLS mutations undermine non-homologous end joining in centromeric instability syndrome. Journal of Clinical Investigation 129(1): 78-92, 2019
- Matsuda S, Yasukawa T, Sakaguchi Y, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D: Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA. Scientific Reports 8(1): 5801, 2018
- Maenohara S, Unoki M*, Toh H, Ohishi H, Sharif J, Koseki H, Sasaki H: Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos. PLoS Genetics 13(10): e1007042, 2017
- Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, Unoki M, Yoshihara M, Suyama M, Sun Y, Lemmers RJ, de Greef JC, Gennery A, Picco P, Kloeckener-Gruissem B, Güngör T, Reisli I, Picard C, Kebaili K, Roquelaure B, Iwai T, Kondo I, Kubota T, van Ostaijen-Ten Dam MM, van Tol MJ, Weemaes C, Francastel C, van der Maarel SM, Sasaki H: Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome. Nature Communications 6: 7870, 2015
- Nitta H, Unoki M, Ichiyanagi K, Kosho T, Shigemura T, Takahashi H, Velasco G, Francastel C, Picard C, Kubota T, Sasaki H: Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients. Journal of Human Genetics 58(7): 455-460, 2013
- Unoki M*, Masuda A, Dohmae N, Arita K, Yoshimatsu M, Iwai Y, Fukui Y, Ueda K, Hamamoto R, Shirakawa M, Sasaki H, Nakamura Y: Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). Journal of Biological Chemistry 28(9): 6053-6062, 2013
- Kofunato Y, Kumamoto K, Saitou K, Hayase S, Okayama H, Miyamoto K, Sato Y, Katakura K, Nakamura I, Ohki S, Koyama Y, Unoki M, Takenoshita S: UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer. Oncology Reports 28(6): 1997-2002, 2012
- Arita K, Isogai S, Oda T, Unoki M, Sugita K, Sekiyama N, Kuwata K, Hamamoto R, Tochio H, Sato M, Ariyoshi M, Shirakawa M: Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1. Proceedings of the National Academy of Sciences of United States of America 109(32): 12950-12955, 2012
- Mori T, Ikeda DD, Yamaguchi Y, Unoki M, NIRF Project: NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape (Review). FEBS Letters 586(11)：1570-1583, 2012
- Hayami S, Kelly JD, Cho HS, Yoshimatsu M, Unoki M, Tsunoda T, Field HI, Neal DE, Yamaue H, Ponder BA, Nakamura Y, Hamamoto R: Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. International Journal of Cancer 128(3): 574-586, 2011
- Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, Nakamura Y, Hamamoto R: Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. International Journal of Cancer 128(3): 562-573, 2011
- Cho HS, Suzuki T, Dohmae N, Hayami S, Unoki M, Yoshimatsu M, Toyokawa G, Takawa M, Chen T, Kurash JK, Field HI, Ponder BA, Nakamura Y, Hamamoto R: Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Research 71(3): 655-660, 2011
- Unoki M*: Current and potential anticancer drugs targeting members of the UHRF1 complex including epigenetic modifiers (Review). Recent Patents on Anti-Cancer Drug Discovery 6(1): 116-130, 2011
- Unoki M*, Daigo Y, Koinuma J, Tsuchiya E, Hamamoto R, Nakamura Y: UHRF1 is a novel diagnostic marker of lung cancer. British Journal of Cancer 103(2): 217-222, 2010
- Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, Field HI, Kelly JD, Neal DE, Yamaue H., Ponder BAJ, Nakamura Y, Hamamoto R: Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Molecular Cancer 9, 59, 2010
- Unoki M*, Kelly JD, Neal DE, Ponder BA, Nakamura Y, Hamamoto R: UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer. British Journal of Cancer 101(1): 98-105, 2009
- Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, *Harris CC: ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. International Journal of Cancer 125(6): 1306-1315, 2009
- Unoki M, Kumamoto K, Takenoshita S, Harris CC: Reviewing the current classification of inhibitor of growth family proteins (Review). Cancer Science 100(7): 1173-1179, 2009
- Unoki M, Kumamoto K, Harris CC: ING proteins as potential anticancer drug targets (Review). Current Drug Targets 10(5): 442-454, 2009
- Unoki M*, Brunet, J, Mousli M: Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis (Review). Biochemical Pharmacology 78(10): 1279-1288, 2009
- Brunet J, Pfaff AW, Abidi A, Unoki M, Nakamura Y, Guinard M, Klein JP, Candolfi E, Mousli M: Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation. Cellular Microbiology 10(4): 908-920, 2008
- Unoki M, Kumamoto K, Robles AI, Shen JC, Zheng ZM, *Harris CC: A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. FEBS Letters 582(28): 3868-3874, 2008
- Unoki M*, Bronner C, Mousli M: A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1. Radiation Research 169(2): 240-244, 2008
- Shen JC, Unoki M, Ythier D, Duperray A, Varticovski L, Kumamoto K, Pedeux R, Harris CC: Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1. Cancer Research 67(6): 2552-2558, 2007
- Unoki M, Shen JC, Zheng ZM, Harris CC: Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. Journal of Biological Chemistry 281(45): 34677-34686, 2006
- Unoki M, Nishidate T, Nakamura Y: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene 23(46): 7601-7610, 2004
- Unoki M, Okutsu J, Nakamura Y: Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. International Journal of Oncology 22(6): 1217-1223, 2003
- Unoki M, Nakamura Y: Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity. FEBS Letters 554(1-2): 567-572, 2003
- Unoki M, Nakamura Y: EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK. Oncogene 22(14): 2172-218, 2003
- Suzuki C, Unoki M, Nakamura Y: Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes. Journal of Human Genetics 46(3): 155-157, 2001
- Takeoka S, Unoki M, Onouchi Y, Doi S, Fujiwara H, Miyatake A, Fujita K, Inoue I, Nakamura Y, Tamari M: Amino-acid substitutions in the IKAP gene product significantly increase risk for bronchial asthma in children. Journal of Human Genetics 46(2): 57-63, 2001
- Yamada R, Tanaka T, Unoki M, Nagai T, Sawada T, Ohnishi Y, Tsunoda T, Yukioka M, Maeda A, Suzuki K, Tateishi H, Ochi T, Nakamura Y, Yamamoto K：Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease. American Journal of Human Genetics 68(3): 674-685, 2001
- Unoki M, Nakamura Y: Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene 20(33): 4457-4465, 2001
- Matsushima-Nishiu M, Unoki M, Ono K, Tsunoda T, Minaguchi T, Kuramoto H, Nishida M, Satoh T, Tanaka T, Nakamura Y: Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN. Cancer Research 61(9): 3741-3749, 2001
- Unoki M, Furuta S, Onouchi Y, Watanabe O, Doi S, Fujiwara H, Miyatake A, Fujita K, Tamari M, Nakamura Y: Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene. Human Genetics 106(4): 440-446, 2000
