Human Genetics is a field focusing on the diversity of the human genome, and can include studies into the molecular mechanisms of genetics, evolutionary history of homo sapiens, cancer genome, as well as susceptibility genes for common and rare diseases. The findings of such genetic studies have proven useful in many applications, from supporting clinical diagnosis of diseases to drug development and therapy. Recent advancements in genomic analyses have allowed us to obtain enormous amounts of genetic and transcriptomic data. Such data will continue to grow in size and utilization in society, reflecting the increasing importance of the field of human genetics.
Our department dives headlong into analyses of genomic, transcriptomic and epigenomic data to evaluate diversity in the human genome, as well as identifying variants and elucidating their functional importance and potential therapeutic applications. Our approach is holistic, focusing not only on data analysis, but also on practical experiments to reach our goal of uncovering new knowledge.
| 2023.10.1 | Ms.Aye Chan Pyae participated as a first-year doctoral student and Ms.Fan Fangling participated as a Research student. | 2023.7.12 | A paper by graduate student Ms. Yoshida has been published in the journal Human Genetics. In this paper, we conducted long-read sequencing analysis to elucidate the chromosome structure of a trisomy patient with an additional chromosome 21 containing two centromeres, which was discovered by Prof. Takako Takano (Tokyo Kasei University). Additionally, we performed transcriptome and DNA methylation analyses on the patient's blood cells and discussed the molecular mechanism behind the generation of the chromosome and its role in the patient's pathology. 論文 |
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| 2023.5.25 | An article, of which Dr. Motoko Unoki is a correspondence author, has been published in Life Sci Alliance. article |
| 2023.04.12 | RESERCH, MEMBERS, and PUBLICATION were updated. |
| 2023.04.1 | Fourth-year undergraduate students Mr. Iwamoto, Mr. Kodama, Mr. Soeda, and Ms. Furumoto participated as graduate students. Dr. Igarashi joined our laboratory as a project researcher, and Ms. Hosaka joined as a technical staff. |
| 2023.03.24 | Mr. Kuribayashi, Ms. Yumura, and Ms. Arimatsu received their bachelor's degrees. Ms. Yumura received the departmental award. | 2023.03.23 | Mr. Ikemoto, Ms. Yoshida, and Mr. Gochi received their master's degrees. | 2023.03.9 | An article by a Ph.D. student, Mr. Ko Ikemoto, has been published in Hum Genomics. We developed the LoMA method to construct highly accurate sequences from multiple read sequences by analyzing long read sequencing data. Using this method, we identified long insertions, repeat extensions, and repeat polymorphisms in transposons in human genome. article |
2022.12.2 | An article by Dr. Motoko Unoki has been published in Hum Mol Genet. article |
2022.10.1 | A review article by Dr. Motoko Unoki has been published in Proc Jpn Acad Ser B Phys Biol Sci. article |
2022.09.01 | Dr. Motoko Unoki has joined our lab as an associate professor. |
| 2022.09.01 | An article by a Ph.D. student, Mr. Leo Gochi, has been published in Hum Genet. We comprehensively analyzed microsatellite polymorphisms of approximately 1,000 individuals. article |
| 2022.08.2 | An article by Mr. Hiroki Kiyose, a Ph.D. student, has been published in PLoS Genet. We developed software to analyze cDNA sequencing data by long-read sequencing and analyzed transcriptional aberrations in hepatocellular carcinoma. article |
| 2022.06.15 | An article by Ph.D. student Dr. Yusuke Sano (Department of Ophthalmology, Kyushu University) has been published in J Med Genet. Using long read sequencing, we discovered structural abnormalities that cause retinitis pigmentosa. article Press Release |
2022.03.25 | Mr. Yuya Nagura, a 4th grade undergraduate student, received the departmental award. | 2021.10.18 | Ph.D. student, Mr. Hiroki Kiyose was selected as a semi-finalist for the ASHG/Charles J. Epstein Trainee Award. | 2020.05.01 | The labo's website has been renewed. |