メンバー紹介

miyagawa
氏名
宮川 卓(みやがわ たく)博士(保健学)
Taku Miyagawa, PhD
生年月日
昭和50年2月3日(41歳)
出身地
神奈川県

ひとこと

睡眠障害はまだまだ分からないことが多い疾患です。
人類遺伝学のアプローチからその病態解明を目指しています。

研究内容

睡眠障害の感受性遺伝子の探索及び治療への応用

学歴

平成10年
東京大学医学部健康科学・看護学科 卒業
平成12年
東京大学大学院医学系研究科国際保健学専攻 修士課程 修了
平成20年
東京大学大学院医学系研究科国際保健学専攻 博士後期課程 修了

略歴

平成12-17年
グラクソ・スミスクライン株式会社開発本部
平成18-20年
日本学術振興会 特別研究員(DC2)
平成20年
東京大学大学院医学系研究科国際保健学専攻人類遺伝学分野 特任研究員
平成20年
東京大学大学院医学系研究科国際保健学専攻人類遺伝学分野 助教
平成27年
東京都医学総合研究所 精神行動医学研究分野 主席研究員

所属学会

  • 日本人類遺伝学会
  • 日本組織適合性学会
  • American Society for Human Genetics
  • 発表論文

    (宮川卓がcorresponding authorである論文には名前に*を付けました)

  • Evaluation of polygenic risks for narcolepsy and essential hypersomnia. Yamasaki M, Miyagawa T, Toyoda H, Khor SS, Liu X, Kuwabara H, Kano Y, Shimada T, Sugiyama T, Nishida H, Sugaya N, Tochigi M, Otowa T, Okazaki Y, Kaiya H, Kawamura Y, Miyashita A, Kuwano R, Kasai K, Tanii H, Sasaki T, Honda Y, Honda M, Tokunaga K. J Hum Genet, 61:873-878, (2016)
  • Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population. Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor SS, Omae Y, Toyo-oka L, Sugaya N, Kawamura Y, Umekage T, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. Hum Genome Var, 3:16001, (2016)
  • Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy. Hoshino A, Saitoh M, Miyagawa T, Kubota M, Takanashi J, Miyamoto A, Tokunaga K, Oka A, and Mizuguchi M. Genes Immun, 17:367–369, (2016)
  • Phenome-wide association study maps new diseases to the human major histocompatibility complex region. Liu J, Ye Z, Mayer JG, Hoch BA, Green C, Rolak L, Cold C, Khor SS, Zheng X, Miyagawa T, Tokunaga K, Brilliant MH, and Hebbring SJ. J Med Genet, 53:681-689, (2016)
  • Identification of ITPA on Chromosome 20 as a susceptibility gene to young-onset Tuberculosis. Nakauchi A, Wong JH, Mahasirimongkol S, Yanai H, Yuliwulandari R, Akihiko Mabuchi A, Liu X, Mushiroda T, Wattanapokayakit S, Miyagawa T, Keicho N, and Tokunaga K. Hum Genome Var 3:15067, (2016)
  • An association analysis of HLA-DQB1 gene in Japanese narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time. Miyagawa T*, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Y Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Ikegami A, Wada Y, Imai M, Fujimura Y, Tamura Y, Omata N, Kondo H, Moriya S, Furuya H, Kato M, Kojima H, Kashiwase K, Saji H, Khor S-S, Yamasaki M, Hirataka A, Ishigooka J, Wada Y, Chiba S, Yamada N, Okawa M, Kuroda K, Kume K, Hirata K, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K. Human Genome Variation 2: 15031, 2015
  • A polymorphism in CCR1/CCR3 is associated with narcolepsy. Toyoda H, Miyagawa T, Koike A, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Imai M, Fujimura Y, Tamura Y, Ikegami A, Wada Y, Moriya S, Furuya H, Takeuchi M, Kirino Y, Meguro A, Remmers EF, Kawamura Y, Otowa T, Miyashita A, Kashiwase K, Khor SS, Yamasaki M, Kuwano R, Sasaki T, Ishigooka J, Kuroda K, Kume K, Chiba S, Yamada N, Okawa M, Hirata K, Mizuki N, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K. Brain, Behavior, and Immunity, Brain Behav Immun 49: 148–155, 2015.
  • Immune-related pathways including HLA-DRB1∗13:02 are associated with panic disorder. Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor SS, Kashiwase K, Sugaya N, Kawamura Y, Umekage T, Kojima H, Saji H, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Tokunaga K, Sasaki T. Brain, Behavior, and Immunity, Volume 46, May 2015, Pages 96–103 (2015)
  • New susceptibility variants to narcolepsy identified in HLA class II region. Miyagawa T*, Toyoda H, Hirataka A, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Imai M, Fujimura Y, Tamura Y, Ikegami A, Wada Y, Moriya S, Furuya H, Kato M, Omata N, Kojima H, Kashiwase K, Saji H, Khor SS, Yamasaki M, Wada Y, Ishigooka J, Kuroda K, Kume K, Chiba S, Yamada N, Okawa M, Hirata K, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, and Tokunaga K. Hum Mol Genet. 24(3):891-8, (2015)
  • Genome-wide analysis of CNV (copy number variation) and their associations with narcolepsy in a Japanese population. Yamasaki M, Miyagawa T*, Toyoda H, Khor SS, Koike A, Nitta A, Akiyama K, Sasaki T, Honda M, Tokunaga K. Journal of Human Genetics, 59(5):235-40, (2014)
  • Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. Khor SS, Miyagawa T*, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E, Tokunaga K. PeerJ, 1:e66, (2013)
  • Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. Miyagawa T, Kawamura H, Obuchi M, Ikesaki A, Ozaki A, Tokunaga K, Inoue Y, Honda M. PLoS One, 8(1):e53707, (2013)
  • Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. Ikeda M, Okahisa Y, Aleksic B, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Sora I, Iyo M, Hashimoto R, Kawamura Y, Nishida N, Miyagawa T, Takeda M, Sasaki T, Tokunaga K, Ozaki N, Ujike H, Iwata N. Neuropsychopharmacology. 38(10):1864-1870, (2013)
  • Genome-wide association study of atypical psychosis. Kanazawa T, Ikeda M, Glatt SJ, Tsutsumi A, Kikuyama H, Kawamura Y, Nishida N, Miyagawa T, Hashimoto R, Takeda M, Sasaki T, Tokunaga K, Koh J, Iwata N, Yoneda H. American Journal of Medical Genetics, 162(7):679-686, (2013)
  • Meta-analysis of genome-wide association studies for Panic disorder in the Japanese population. Otowa T, Kawamura Y, Nishida N, Sugaya N, Koike A, Yoshida E, Inoue K,Yasuda S, Nishimura Y, Liu X, Konishi Y, Nishimura F, Shimada T, Kuwabara H, Tochigi M, Kakiuchi C, Umekage T, Miyagawa T, Miyashita A, Shimizu E, Akiyoshi J, Someya T, Kato T, Yoshikawa T, Kuwano R, Ihara Y, Kasai K, Kato N, Kaiya H, Tokunaga K, Okazaki Y, Tanii H, Sasaki T. Translational Psychiatry. 2012(2), e186, (2012)
  • Common variants in P2RY11 are associated with narcolepsy. Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Nature Genetics, 43(1):66-71, (2011)
  • Abnormally low serum acylcarnitine levels in narcolepsy patients. Miyagawa T*, Miyadera H, Tanaka S, Kawashima M, Shimada M, Honda Y, Tokunaga K, Honda M. Sleep, 34(3):349-53, (2011)
  • Association study of PDE4B with panic disorder in the Japanese population. Otowa T, Kawamura Y, Sugaya N, Yoshida E, Shimada T, Liu X, Tochigi M, Umekage T, Miyagawa T, Nishida N, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(2):545-549, (2011)
  • Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. Miyagawa T*, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, Tokunaga K. Journal of Human Genetics, 55(1):63-65, (2010)
  • An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, Miyagawa T*, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. Human Genetics, 128(4):433-441, (2010)
  • Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy. Toyoda H, Tanaka S, Miyagawa T, Honda Y, Tokunaga K, Honda M. Sleep, 33(7):875-878, (2010)
  • Replication of a genome-wide association study of panic disorder in a Japanese population. Otowa T, Tanii H, Sugaya N, Yoshida E, Inoue K, Yasuda S, Shimada T, Kawamura Y, Tochigi M, Minato T, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Okazaki Y, Kaiya H, Sasaki T. Journal of Human Genetics, 55(2):91-96 (2010)
  • Association of the oxytocin receptor (OXTR) gene polymorphisms autism spectrum disorder (ASD) in Japanese population. Liu X, Kawamura Y, Shimada T, Otowa T, Koishi S, Sugiyama T, Nishida H, Hashimoto O, Nakagami R, Tochigi M, Umekage T, Kano Y, Miyagawa T, Kato N, Tokunaga K, Sasaki T. Journal of Human Genetics, 55(3): 137-141 (2010)
  • Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). Miyagawa T*, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, Tokunaga K. PloS One, 4(4): e5394, (2009)
  • Narcolepsy. Miyagawa T, Tokunaga K. MHC, 16(1):39-48, (2009)
  • FGFR2 is associated with hair thickness in Asian populations. Fujimoto A, Nishida N, Kimura R, Miyagawa T, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Tsunoda T, Tokunaga K, Ohashi J. Journal of Human Genetics, 54(8):461-465, (2009)
  • Genome-wide association study of panic disorder in the Japanese population. Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, Okazaki Y. Journal of Human Genetics, 54(2):122-126, (2009)
  • Narcolepsy is strongly associated with the T-cell receptor alpha locus. Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SC, Honda Y, Honda M, Högl B, Longstreth WT Jr, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poli F, Frauscher B, Jeong JH, Lee SP, Ton TG, Kvale M, Kolesar L, Dobrovolná M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok PY, Risch N, Mignot E. Nature Genetics, 41(6):708-11, (2009)
  • Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Miyagawa T, Kawashima M, Nishida N, Ohashi J, Kimura R, Fujimoto A, Shimada M, Morishita S, Shigeta T, Lin L, Hong SC, Faraco J, Shin YK, Jeong JH, Okazaki Y, Tsuji S, Honda M, Honda Y, Mignot E, Tokunaga K. Nature Genetics, 40(11):1324-1328, (2008)
  • Appropriate data cleaning methods for genome-wide association study. Miyagawa T, Nishida N, Ohashi J, Kimura R, Fujimoto A, Kawashima M, Koike A, Sasaki T, Tanii H, Otowa T, Momose Y, Nakahara Y, Gotoh J, Okazaki Y, Tsuji S, Tokunaga K. Journal of Human Genetics, 53(10):886-893, (2008) (JHG賞受賞論文)
  • A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia. Fujimoto A, Ohashi J, Nishida N, Miyagawa T, Morishita Y, Tsunoda T, Kimura R, Tokunaga K. Human Genetics, 124(2):179-185, (2008)
  • Polymorphisms of promoter and coding regions of the arylamine N-acetyltransferase 2 (NAT2) gene in the Indonesian population: proposal for a new nomenclature. Yuliwulandari R, Sachrowardi Q, Nishida N, Takasu M, Batubara L, Susmiarsih TP, Rochani JT, Wikaningrum R, Miyashita R, Miyagawa T, Sofro AS, Tokunaga K. Journal of Human Genetics, 53(3): 201-209, (2008)
  • Case-control study with narcoleptic patients and healthy controls who, like the patients, possess both HLA-DRB1*1501 and -DQB1*0602. Hohjoh H, Terada N, Nakayama T, Kawashima M, Miyagawa T, Honda Y, Tokunaga K. Tissue Antigens 57(3), 230-235, (2001)
  • Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy. Miyagawa T, Hohjoh H, Honda Y, Juji T, Tokunaga K. Immunogenetics 52(1-2): 12-18, (2000)
  • Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy. Hohjoh H, Nakayama T, Ohashi J, Miyagawa T, Tanaka H, Akaza T, Honda Y, Juji T, Tokunaga K. Tissue Antigens 54(2): 138-145, (1999)
  • 受賞歴

    平成23年
    日本人類遺伝学会JHG賞
    平成25年
    日本人類遺伝学会奨励賞